ID B8LVM6_TALSN Unreviewed; 956 AA.
AC B8LVM6;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Coatomer subunit beta {ECO:0000256|PIRNR:PIRNR005727};
DE AltName: Full=Beta-coat protein {ECO:0000256|PIRNR:PIRNR005727};
GN ORFNames=TSTA_075280 {ECO:0000313|EMBL:EED24156.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED24156.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
CC {ECO:0000256|PIRNR:PIRNR005727}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000256|PIRNR:PIRNR005727}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR005727}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR005727}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR005727};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR005727}. Cytoplasmic vesicle, COPI-coated
CC vesicle membrane {ECO:0000256|PIRNR:PIRNR005727}; Peripheral membrane
CC protein {ECO:0000256|PIRNR:PIRNR005727}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR005727}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; EQ962652; EED24156.1; -; Genomic_DNA.
DR RefSeq; XP_002341543.1; XM_002341502.1.
DR AlphaFoldDB; B8LVM6; -.
DR STRING; 441959.B8LVM6; -.
DR GeneID; 8099982; -.
DR VEuPathDB; FungiDB:TSTA_075280; -.
DR eggNOG; KOG1058; Eukaryota.
DR HOGENOM; CLU_006949_0_0_1; -.
DR InParanoid; B8LVM6; -.
DR OMA; MDYIIPA; -.
DR OrthoDB; 151169at2759; -.
DR PhylomeDB; B8LVM6; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR011710; Coatomer_bsu_C.
DR InterPro; IPR016460; COPB1.
DR InterPro; IPR029446; COPB1_appendage_platform_dom.
DR PANTHER; PTHR10635; COATOMER SUBUNIT BETA; 1.
DR PANTHER; PTHR10635:SF0; COATOMER SUBUNIT BETA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF07718; Coatamer_beta_C; 1.
DR Pfam; PF14806; Coatomer_b_Cpla; 1.
DR PIRSF; PIRSF005727; Coatomer_beta_subunit; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005727};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR005727};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005727};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005727}.
FT DOMAIN 21..490
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT DOMAIN 680..816
FT /note="Coatomer beta subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07718"
FT DOMAIN 821..947
FT /note="Coatomer beta subunit appendage platform"
FT /evidence="ECO:0000259|Pfam:PF14806"
SQ SEQUENCE 956 AA; 106492 MW; A4C01D3148F8769D CRC64;
MASYLENAYS LVHQDNSADQ PSLQELKMQL EKGTDETKQE TMRRIITIML NGDPMAGLLM
HIIRFVMPSK NKPLKKLLYF YYEICPKHDA NGKLKQEMIL VCNGIRNDLQ HPNEYIRGNT
LRFLCKLREP ELIEPLLSSA RSCLEHRHAY VRKNAVWAIS SIYQHSESLI PDAPELIQTF
LDSESDHTCK RNAFAALMSI SHQKALEYLS QTFDSIPNAD ELLQLAELEF IRKDAVQNAQ
NKARYLRLIF DLLDASASTV IYEAATSLTA LTSNPVAVKA AASKLIELSI KEADNNVKLI
VLDRVDQLRI RNEGVLEDLT MEILRVLSSP DIDVRRKALS IAMEMVSSKN VEEIVMLLKK
ELAKTVDEQY EKSSEYRQLL IQSIHLCAIK FSEIAASVVD LLMDFIGDFN NNSAVDVISF
VKEVVEKFPK LRPSIIERLV ATLSEVRAGK VYRGVLWVVG EYSLETSDIR EAWKRIRASL
GEIPILASEQ RLLDEVPDDN ATVLDQVNGH SKAAAPSGSR KVLADGTYAT ESALTSQSAA
AAKLEAVKAA QKPPLRQLIL DGDYYLATVL SSTLTKLVMR HSEVSQDAAR TNALRAEAML
IMISIVRVGQ SQFVKAPIDE DSVDRIMTCV RALSEFSERK ELETTFLEDT RKAFKTIVQT
EEKKRAAKAA SEKAKTAVQI DDAIPIRQLT KKNAGEGTDE IELDLIKATG GDATVEDLSS
KLSRIVQLTG FSDPVYAEAY VQVHQFDIIL DVLLVNQTTE TLQNLSVEFA TLGDLKVVER
PTTQNLGPRD FLNVQATVKV SSTDAGVIFG NVVYDGSSST ETHVVILNDI HADIMDYIQP
AHCTETQFRT MWTEFEWENK VNINSKAKDL REFLKQLMES TNMTCLTPEA SLQGDCQFLS
ANLYARSVFG EDALANLSIE KEGEDGPITG FVRIRSRSQG LALALGNLKG LKASAA
//
