ID B8LYB8_TALSN Unreviewed; 716 AA.
AC B8LYB8;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=Sorting nexin MVP1 {ECO:0000256|ARBA:ARBA00014268};
GN ORFNames=TSTA_063290 {ECO:0000313|EMBL:EED22848.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED22848.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- FUNCTION: Required for vacuolar protein sorting.
CC {ECO:0000256|ARBA:ARBA00002474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; EQ962652; EED22848.1; -; Genomic_DNA.
DR RefSeq; XP_002340235.1; XM_002340194.1.
DR AlphaFoldDB; B8LYB8; -.
DR STRING; 441959.B8LYB8; -.
DR GeneID; 8104688; -.
DR VEuPathDB; FungiDB:TSTA_063290; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_009058_1_0_1; -.
DR InParanoid; B8LYB8; -.
DR OrthoDB; 45524at2759; -.
DR PhylomeDB; B8LYB8; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR035704; SNX8/Mvp1_PX.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR47554; SORTING NEXIN MVP1; 1.
DR PANTHER; PTHR47554:SF1; SORTING NEXIN MVP1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 336..451
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 78843 MW; 91DB63FFADE8F6C7 CRC64;
MSLFGTSPDE TSTEVNPSRL SKSSLFDDEP SHSQSGSALF ADDNHGGDSP WDMPTPKRGG
RQNLVKNLLP ASDVPDSYIN GFDLVLDSSG RGGAGVGLTT TRQILASSGL TAANQAKILN
LVLPGGQEAS SEGLGRNEFN VLLALIGLAQ EGEEITFDAV DERRNKLPQP KISYLDELRH
SNAEPASTTQ QPGETQQPGS QQQPVHARPR QTSFGTPEAD PWGSPDLHRG HSHISTHEST
LNGFGSVRSS TNGWGTATSA ATANESQSTV QSNGQGPPSS SGSGWGGYNN TSQTAPFGST
AQPGFEAFPQ PGNAQEGIDP QGRSLGGGRV TGPGAEEVVT VTLLPEKEGL FMFQHRNYEV
KSARRGSSVV RRYSDFVWLL DCLHKRYPFR QLPLLPPKRV AVNGTHLSAD SNSFLEKRRR
GLVRFTNALV RHPVLNQEQL VVMFLTVPTE LSVWRKQATI SVQEEFAGKT LPPDLEDSLP
STLNETFDTV RSGVKRSAEI FINLCALLER LAKRNEGLAA DHLRFSLALQ SLTEATKNTY
AVDTNDVPLL NEGINATARH LSVSQSLLED EARAWTDGVL EDLKQQRDCV VSMRDLFDRR
DRLAKDNIPQ LEKRIETNER KLQDLRSRPQ GTVKPGEIEK IEESIFKDKE SIVQQHARGV
FIKECIRDEL LYFQHSQYHI SRLHQDWSQE RVKYAELQAD NWRGLSEEVE GMPTGE
//
