ID B8M325_TALSN Unreviewed; 576 AA.
AC B8M325;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=glycerol kinase {ECO:0000256|ARBA:ARBA00012099};
DE EC=2.7.1.30 {ECO:0000256|ARBA:ARBA00012099};
GN ORFNames=TSTA_092440 {ECO:0000313|EMBL:EED22001.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED22001.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005190}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
CC {ECO:0000256|ARBA:ARBA00009156, ECO:0000256|RuleBase:RU003733}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EQ962653; EED22001.1; -; Genomic_DNA.
DR RefSeq; XP_002478964.1; XM_002478919.1.
DR AlphaFoldDB; B8M325; -.
DR STRING; 441959.B8M325; -.
DR GeneID; 8099425; -.
DR VEuPathDB; FungiDB:TSTA_092440; -.
DR eggNOG; KOG2517; Eukaryota.
DR HOGENOM; CLU_009281_2_2_1; -.
DR InParanoid; B8M325; -.
DR OMA; VQWMRDQ; -.
DR OrthoDB; 2734344at2759; -.
DR PhylomeDB; B8M325; -.
DR UniPathway; UPA00618; UER00672.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd07795; FGGY_ScGut1p_like; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018485; FGGY_C.
DR InterPro; IPR018484; FGGY_N.
DR InterPro; IPR005999; Glycerol_kin.
DR NCBIfam; TIGR01311; glycerol_kin; 1.
DR PANTHER; PTHR10196:SF75; GLYCEROL KINASE; 1.
DR PANTHER; PTHR10196; SUGAR KINASE; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycerol metabolism {ECO:0000256|ARBA:ARBA00022798};
KW Kinase {ECO:0000256|RuleBase:RU003733, ECO:0000313|EMBL:EED22001.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transferase {ECO:0000256|RuleBase:RU003733, ECO:0000313|EMBL:EED22001.1}.
FT DOMAIN 10..262
FT /note="Carbohydrate kinase FGGY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00370"
FT DOMAIN 272..460
FT /note="Carbohydrate kinase FGGY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02782"
SQ SEQUENCE 576 AA; 63339 MW; D4189088116849BA CRC64;
MPGLTESFVG SIDQGTTSTR FLIFNRDGEP VASHQVEFEQ IYPNPGWHEH DPLELVSSVE
TCIEEAVKKF EEIGHTRESI KAIGITNQRE TTVLWDSETG EPLHNAIVWT DTRSQTIVRE
LRSRKGAEDL QQICGLPLST YPSSTKLLWM VKNVPKVKEA YDKGRLAFGT VDSWLVYKLN
GGPAANVFVS DPTNASRTMF MNLATLEYDD RLLDFFGVKG KIHLPRIVPS SDRKSYGNIS
SGILEGVPIM GCLGDQSSAL VGQKGFYPGL AKNTYGTGCF LLYNVGEKPV ISKHGLLATV
AFQFDGKPVY ALEGSIAVGG SGVRFLQNNL SLFKESKDIN ELAATVEDNG GCIFVTAFSG
LFAPYWIDDA KGTIFGITQY TQKGHIARAT LEATCYQTKA ILDAMEKDSG HALSELAVDG
GMSNSDLAMQ IQADLVSIPV YRPKMRETTA LGAAIAAGLA LGLWRNFTEL RDINRAGGAV
FEPSVPPEKS AEMFALWEKA VQMSKGWVKK DNENINGVHQ IRRPSVIANG KPNEPVFITQ
SVYDDLDGAD EEDLLLELRK IEIQQRLKRL RKESKS
//
