ID B8M842_TALSN Unreviewed; 534 AA.
AC B8M842;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=O-acyltransferase {ECO:0000256|PIRNR:PIRNR000439};
GN ORFNames=TSTA_032590 {ECO:0000313|EMBL:EED20004.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED20004.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- FUNCTION: Sterol O-acyltransferase that catalyzes the formation of
CC stery esters. {ECO:0000256|ARBA:ARBA00023568}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|PIRNR:PIRNR000439}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|PIRNR:PIRNR000439}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
CC Sterol o-acyltransferase subfamily. {ECO:0000256|ARBA:ARBA00009010,
CC ECO:0000256|PIRNR:PIRNR000439}.
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DR EMBL; EQ962654; EED20004.1; -; Genomic_DNA.
DR RefSeq; XP_002480438.1; XM_002480393.1.
DR AlphaFoldDB; B8M842; -.
DR STRING; 441959.B8M842; -.
DR GeneID; 8099872; -.
DR VEuPathDB; FungiDB:TSTA_032590; -.
DR eggNOG; KOG0380; Eukaryota.
DR InParanoid; B8M842; -.
DR OMA; FICQMLQ; -.
DR OrthoDB; 9612at2759; -.
DR PhylomeDB; B8M842; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR InterPro; IPR004299; MBOAT_fam.
DR InterPro; IPR014371; Oat_ACAT_DAG_ARE.
DR PANTHER; PTHR10408:SF26; O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR10408; STEROL O-ACYLTRANSFERASE; 1.
DR Pfam; PF03062; MBOAT; 1.
DR PIRSF; PIRSF000439; Oat_ACAT_DAG_ARE; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|PIRNR:PIRNR000439,
KW ECO:0000313|EMBL:EED20004.1};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|PIRNR:PIRNR000439};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR000439};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transferase {ECO:0000256|PIRNR:PIRNR000439, ECO:0000313|EMBL:EED20004.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 28..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 471
FT /evidence="ECO:0000256|PIRSR:PIRSR000439-1"
SQ SEQUENCE 534 AA; 61145 MW; 748DCF44FF20AAD3 CRC64;
MSTATSNGSM TSQVLRARAI KSLQAADERL GTSNSIPDKE NADSSGASTP VPEDAPPSVK
SISTARKQVR ARRRLFHTID YIPRVSHFDP QSDYHNFRGF FTLFWIGLFI MVVTTVLRNI
KDTGHPLRVK MWSLLTANVW QLAISDLAMV VSSGLALPIQ KLTRKGGNIL RWYRAGILIQ
SLYQIAWLTL WIKWPFMLHW TWTAQVFFTL HTLTILMKVH SYAFYNGHLS ETERRLSELD
KPGQGSMAAA VRYPSSPARA ETMNGSFEIK GEEPLSRLRD DLATELTSPL GQVTYPQNLT
LGNFVDFLFC PTLCYEIEYP RTPSIRWTEV FFKALAVFGC IFLLTLTSEE FIVPVLHEAS
ISLSSVNTWS DQALILAETT SMLLFPFMIT FLLVFLVIFE YLLGAFAEIT RFADRRFYSD
WWNSCDWLEF SREWNIPVHH FLRRHVYFSS KAYFSAPVAM FITFLVSALA HELVMSCITK
KLRGYGFLLM MLQLPIIAIQ RTPLIRQAKT WNNIVFWFSM ILGLSMMCAL YVLV
//
