ID   B8M8N6_TALSN            Unreviewed;       944 AA.
AC   B8M8N6;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=TSTA_037670 {ECO:0000313|EMBL:EED20549.1};
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS   1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441959 {ECO:0000313|EMBL:EED20549.1, ECO:0000313|Proteomes:UP000001745};
RN   [1] {ECO:0000313|Proteomes:UP000001745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC   {ECO:0000313|Proteomes:UP000001745};
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
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DR   EMBL; EQ962654; EED20549.1; -; Genomic_DNA.
DR   RefSeq; XP_002480983.1; XM_002480938.1.
DR   AlphaFoldDB; B8M8N6; -.
DR   STRING; 441959.B8M8N6; -.
DR   GeneID; 8102143; -.
DR   VEuPathDB; FungiDB:TSTA_037670; -.
DR   eggNOG; KOG1075; Eukaryota.
DR   HOGENOM; CLU_000680_26_3_1; -.
DR   InParanoid; B8M8N6; -.
DR   OMA; PEYWRIN; -.
DR   OrthoDB; 2326875at2759; -.
DR   PhylomeDB; B8M8N6; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..944
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002877596"
FT   DOMAIN          1..431
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          642..788
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
SQ   SEQUENCE   944 AA;  104222 MW;  5D6B9D6DB21D46E7 CRC64;
     MNLRFAALLL SVALAFALPD DILSTWPTST ANNITECSNP RSNDCLFYAQ CLQTRYRCAP
     SDYTLGYGQK YCEKFQADAS LLSTKGQTWM ETVMLCLQRD LVPYTLGGPQ EFANCLALND
     YAFSTHPKCY VQSGLCTLPV HDWEVIVFQI VGVETLFDSW DAIKATVQAA SGCAEFYLWA
     IEHVIPGPLT LGLSVLGKGL ERLVARNMAW ISIHHKVLAR QQFGALPLRS ATDLTTCLTH
     DVEQALNQGM TASLLTLDVK GAFDSVLPGR LIRRLREQGW PTNLVLWIAS FATGRSVQIR
     LDGEIGPSTD IACGLPQGSP VSGILFMLYI APLFRLGNPR NRFGYADDAA NLAISTSLAT
     NCEALSDSLQ EALNWGTAEG ITFAPDKYEL LHFSRHKADQ DPTRTPSVKA GSITISENTK
     RLYLRWLGIL FDKKLTFKWH VRETASKALT VANALRSLGN TVRGVKPDLL QQAVSACVLH
     KAYYGAETWW PGRTRPGPSQ ISNRVGEHLE KLTKVILTGA RAVLPVFRTT PKPVLYRESG
     FSPPEIELDR IALLATVRLR RLDPYHPLRR RAEQIASNGR QTSRFARRTL ALPNSEQINP
     LQYAPWHPRE PRGNAQARIG APMGRTKEQA AANFMAFQRT IPSSDIVIFS DGSRLADGRA
     GGGYIGLQAH HQFLRSSLSY GHGKEVFDAE AEAALAGAQA AIAYPTAQFA TNLWICLDNL
     EVAVRLLSPS TGSSQEIFES FRTLAAAWPL RKRLPHTKSG SIQIRWVPGH AKIPENEAAD
     LAAKEGAASI PPAPHKSSYA SLKRYAKTQS LSAAQSQWEK VAPQSYQDLE ITTSPKRPGE
     LQLNRLDLGH VIAARTGHGD FADYHERFNH DDAYLLCRCG ARKAPLHFFF CYIAKRRAPR
     PPGPPSEVIS FLLGTAKGAQ KLATWLAETH FFEDICPRQP LLST
//