ID B8M970_TALSN Unreviewed; 475 AA.
AC B8M970;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 03-MAY-2023, entry version 58.
DE RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
GN ORFNames=TSTA_112010 {ECO:0000313|EMBL:EED17365.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED17365.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC {ECO:0000256|RuleBase:RU365065}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU365065}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}.
CC -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC ECO:0000256|RuleBase:RU365065}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU365065}.
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DR EMBL; EQ962655; EED17365.1; -; Genomic_DNA.
DR RefSeq; XP_002481357.1; XM_002481312.1.
DR AlphaFoldDB; B8M970; -.
DR STRING; 441959.B8M970; -.
DR GeneID; 8098856; -.
DR VEuPathDB; FungiDB:TSTA_112010; -.
DR eggNOG; KOG2601; Eukaryota.
DR HOGENOM; CLU_020370_5_1_1; -.
DR InParanoid; B8M970; -.
DR OMA; NIGNWVD; -.
DR OrthoDB; 38357at2759; -.
DR PhylomeDB; B8M970; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR009716; Ferroportin-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR PANTHER; PTHR11660:SF57; SOLUTE CARRIER FAMILY 40 PROTEIN; 1.
DR Pfam; PF06963; FPN1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|RuleBase:RU365065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365065};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365065};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT TRANSMEM 186..208
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 214..232
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 280..301
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 348..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 52701 MW; 038031FC0A9C4472 CRC64;
MAGNNPEEQP TQDVEVPTNE PEPALPPSIP SNLAYRLYIS HFLSTWNSRL FEFGSVLFLA
SIYPQTLLPM SVYALVRSGA AIVFSQALGF WIDRGERLAT VQTSIVGQRL AVAGSCVIFG
LLQQENDIIR GGKVKDGLFA VTVVLACVEK LCSVLNTVSI ERDWIVVITE GNEGVRRVMN
ARMRRIDLFC KLVGPLTISL VASASTLIAI RVTFAMSVAS VLVEVLCIAQ VYKAFPQLRR
NEVDEETINT TMQQTSTPAT LVRCLNIGLR NILPISSLRF YFTHPAFVPS FALSLLYFTV
LSFSGQMITY LVSVGYSTLY IGIARTVSTA LELSATWIAP RMMKRVGVVR GGIWSLCWQM
AWLGVGVTWF FANSNREGRD VIIAATGLAV GVALSRIGLW GYDLCAQNLI QDVSQYIHIQ
RKGIDRKDRK SKIRIAENSP PPKPLFKTYS NYCLMRQRSS FQSRRSSSGR SLSVR
//
