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Database: UniProt
Entry: B8MCJ4_TALSN
LinkDB: B8MCJ4_TALSN
Original site: B8MCJ4_TALSN 
ID   B8MCJ4_TALSN            Unreviewed;       689 AA.
AC   B8MCJ4;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   05-JUN-2019, entry version 51.
DE   SubName: Full=Protease S8 tripeptidyl peptidase I, putative {ECO:0000313|EMBL:EED18810.1};
GN   ORFNames=TSTA_125260 {ECO:0000313|EMBL:EED18810.1};
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 /
OS   NRRL 1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces.
OX   NCBI_TaxID=441959 {ECO:0000313|EMBL:EED18810.1, ECO:0000313|Proteomes:UP000001745};
RN   [1] {ECO:0000313|Proteomes:UP000001745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC   {ECO:0000313|Proteomes:UP000001745};
RX   PubMed=25676766; DOI=10.1128/genomeA.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01032};
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DR   EMBL; EQ962655; EED18810.1; -; Genomic_DNA.
DR   RefSeq; XP_002482802.1; XM_002482757.1.
DR   MEROPS; S53.007; -.
DR   EnsemblFungi; EED18810; EED18810; TSTA_125260.
DR   GeneID; 8100305; -.
DR   EuPathDB; FungiDB:TSTA_125260; -.
DR   eggNOG; ENOG410IIY6; Eukaryota.
DR   eggNOG; COG4934; LUCA.
DR   InParanoid; B8MCJ4; -.
DR   OMA; HEHEREG; -.
DR   OrthoDB; 1294880at2759; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001745};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01032,
KW   ECO:0000313|EMBL:EED18810.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    689       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002875024.
FT   DOMAIN      233    688       Peptidase S53. {ECO:0000259|PROSITE:
FT                                PS51695}.
FT   REGION      184    207       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B8MCJ4}.
FT   ACT_SITE    310    310       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    314    314       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    606    606       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       647    647       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
FT   METAL       648    648       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       666    666       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       668    668       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
SQ   SEQUENCE   689 AA;  74442 MW;  70112FB38B3670B4 CRC64;
     MLWQYLLVHT SVFSGALAAS LSPVLHEKRD IPLPEIKQRI DGDAIIPVRI GLRQSNLHTG
     YNRLMEVSHP SSENYGKHLT KEEVHALFAP AEETLDTVKN WLFGTGLVDH SEIIHYENKG
     WLAIDMPAKH AETLLGTHFY EIESHNGDVR IGCEEYYLPA HVSSHVDYIK PGVKLSAPMK
     KKQLPQKRSV AGADSFHPSH PRMPHTRPPH YPGWSLPPAA WGLPPELQNC GVNITPTCIK
     ALYDIPNPIF SQPENAMGLF ETYDAFSQED ISLFFQHFAT NVPAGTKPNV ISVDGGTAPV
     APNDTRNGGE SDIDLDLAIS LIYPQTVTVY QVDDLPNSSG ETGVNGFLNT FLDSVDGSYC
     DYSAFGITGD SPGVDASYPD PATDGYKGQK QCGTYNLTRV VSISYGEAEV YLPKAYVERQ
     CNEILKLGLQ GHTILVASGD YGVASFPGSN GDAEGCLSSG TMNGTIYNPD YPAGCPYITA
     VGATRLYPND TVHDAESAMQ VNLTAFNIAT GAGPTSPPYD FFATGGGFSN YFKPAPFQAL
     AIEEYLKKDL PYQSLPYYEI NADATNIGEK GGVYNRIGRG YPDVSANGAF LLTYVNQTAG
     TFFGTSLASP IFGAVVTLLN EARSAVGKGP IGFINPALYA NPFVLNDITN GSNPNCGSQG
     FQASQGWDPV TGLGTPNFPR MLAYFLSLP
//
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