ID B8MDD4_TALSN Unreviewed; 713 AA.
AC B8MDD4;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 13-SEP-2023, entry version 72.
DE SubName: Full=Methylenetetrahydrofolate reductase {ECO:0000313|EMBL:EED17897.1};
DE EC=1.5.1.20 {ECO:0000313|EMBL:EED17897.1};
GN ORFNames=TSTA_116860 {ECO:0000313|EMBL:EED17897.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED17897.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
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DR EMBL; EQ962655; EED17897.1; -; Genomic_DNA.
DR RefSeq; XP_002481889.1; XM_002481844.1.
DR AlphaFoldDB; B8MDD4; -.
DR STRING; 441959.B8MDD4; -.
DR GeneID; 8102078; -.
DR VEuPathDB; FungiDB:TSTA_116860; -.
DR eggNOG; KOG0564; Eukaryota.
DR HOGENOM; CLU_025841_2_1_1; -.
DR InParanoid; B8MDD4; -.
DR OMA; GVFKTIP; -.
DR OrthoDB; 1381745at2759; -.
DR PhylomeDB; B8MDD4; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF1; METHYLENETETRAHYDROFOLATE REDUCTASE 1; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EED17897.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745}.
SQ SEQUENCE 713 AA; 79375 MW; 06F40E371265D7BE CRC64;
MEKITEKIAA LPPGSNYFSL EFFPPKTQMG SVNLQARLER MAQVLRPLFV TVTWGAGGTT
AAKSLELAEI CQRQLQLTTC LHLTCTNMTR SLIDEALEQA KALGIKNILA LRGDPPRSEE
YNMDGDDDSN KDFTWAIDLV RYIRRTYGDY FCVGVAAYPE GHPGESQTDI QDPEKDLPYL
VEKVQAGADF IMTQLTYDFE TYQKFEERLR NHPSGAIKSI PIIPGLMPIH GYKILTRVTK
LSGAHIPPAI MSRIEQVRSD DERVKQVGVD IVSEIVNQIK SLPNPGHRGY HFYTLNLEKS
VTLILERCDL IPPSSDDDAV EDDIAIEEVA VSNNKDDLKT LVSRRRASSV NSGPYNRVIV
DKLHVPTDQQ SEHSSRKSIT YETLASSAGV PALNPPPRST QLQISEGIGS LGREATWDDF
PNGRWGDSRS PAFGEIDGYG PSLHVNATVA KQLWGFPVTR EDIGALFRKH VSGELYIVPW
SEGGAAEDAN LNAETETIKP QLLQIIEKKN WWTLASQPAV NGVRSDHPVF GWGPPGEGFV
FQKAFVEFFC PSSDYQNKVK PTLLKHGSEE FSWFAINAAG HLESSFLIST SSSPKPEDTS
SAVAAADEEP LEIRESTGMA VTWGAFRGRE ITTPTIIEEV SFRAWGEEAF RIWDEWRRIY
PRGSATERLL NETKNDVWLL CVIGHRYGAG TVPGSEEEKK EMNTLWNVLA GDM
//
