ID B8MKU4_TALSN Unreviewed; 494 AA.
AC B8MKU4;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 03-MAY-2023, entry version 55.
DE RecName: Full=Hsp90 chaperone protein kinase-targeting subunit {ECO:0000256|ARBA:ARBA00031396};
GN ORFNames=TSTA_044100 {ECO:0000313|EMBL:EED14943.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED14943.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the CDC37 family.
CC {ECO:0000256|ARBA:ARBA00006222}.
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DR EMBL; EQ962657; EED14943.1; -; Genomic_DNA.
DR RefSeq; XP_002484896.1; XM_002484851.1.
DR AlphaFoldDB; B8MKU4; -.
DR STRING; 441959.B8MKU4; -.
DR GeneID; 8102709; -.
DR VEuPathDB; FungiDB:TSTA_044100; -.
DR eggNOG; KOG2260; Eukaryota.
DR HOGENOM; CLU_033261_0_0_1; -.
DR InParanoid; B8MKU4; -.
DR OMA; ITTKDHQ; -.
DR OrthoDB; 1329460at2759; -.
DR PhylomeDB; B8MKU4; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR InterPro; IPR004918; Cdc37.
DR InterPro; IPR013873; Cdc37_C.
DR InterPro; IPR013874; Cdc37_Hsp90-bd.
DR InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR InterPro; IPR013855; Cdc37_N_dom.
DR PANTHER; PTHR12800; CDC37-RELATED; 1.
DR PANTHER; PTHR12800:SF4; HSP90 CO-CHAPERONE CDC37; 1.
DR Pfam; PF08564; CDC37_C; 1.
DR Pfam; PF08565; CDC37_M; 1.
DR Pfam; PF03234; CDC37_N; 1.
DR SMART; SM01069; CDC37_C; 1.
DR SMART; SM01070; CDC37_M; 1.
DR SMART; SM01071; CDC37_N; 1.
DR SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745}.
FT DOMAIN 2..192
FT /note="Cdc37 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01071"
FT DOMAIN 191..369
FT /note="Cdc37 Hsp90 binding"
FT /evidence="ECO:0000259|SMART:SM01070"
FT DOMAIN 386..485
FT /note="Cdc37 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01069"
FT REGION 95..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 494 AA; 55401 MW; D3BC3CE7907BDC9E CRC64;
MVLDYSKWDA LELSDDSDIE VHPNVDKRSF IRAKQNQIHQ QRMQRRHEIE TLKYERIIND
GLLERIDKLL GALREHEDSS RNPEELVFQS LIESAGDPAK DQPPAPPAGV YTHEKEQPKY
SQMMSSLVDQ VKKEVTESKA ENTFRAYITG VQGHKDKVLG LQQELLKKLA ELEKEEKSKI
TSDSIHTGFD SSYIAKSDSK AKGKTPATET KVELLNSPSI GKVDGTLSSG AESDAEDDDD
EEADIKVSDL AKKFAKIPMT DYKAMLQFIS ANPEIVAERE TDGLLVEAFN NQMEGKSDYA
RICVHHGLLL QYCRSLGRDG ISLFFKRITT KDHQAATLFR NDVNETYNKI KTRAAELAKN
KSPENDPAGV EQIQLHAVDP NTQINISIPP ADSSNPEEIE ARKIFESFPP NLQRALESAS
LDEVNRVLGK MSVEEAEEIV EKLGHGGMLS LEEGIVDATT EEGRKKLEEI EAEGKKERKQ
EVEEMGEPVE DQLD
//
