ID B8MLT4_TALSN Unreviewed; 1002 AA.
AC B8MLT4;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Polyketide synthase, putative {ECO:0000313|EMBL:EED13801.1};
DE EC=2.3.1.94 {ECO:0000313|EMBL:EED13801.1};
GN ORFNames=TSTA_100460 {ECO:0000313|EMBL:EED13801.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED13801.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
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DR EMBL; EQ962658; EED13801.1; -; Genomic_DNA.
DR RefSeq; XP_002486039.1; XM_002485994.1.
DR AlphaFoldDB; B8MLT4; -.
DR STRING; 441959.B8MLT4; -.
DR GeneID; 8097930; -.
DR VEuPathDB; FungiDB:TSTA_100460; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_16_8_1; -.
DR InParanoid; B8MLT4; -.
DR OMA; WSENTEI; -.
DR OrthoDB; 5396558at2759; -.
DR PhylomeDB; B8MLT4; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF53; ATROCHRYSONE CARBOXYLIC ACID SYNTHASE-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF16073; SAT; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:EED13801.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transferase {ECO:0000313|EMBL:EED13801.1}.
FT DOMAIN 395..778
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 1002 AA; 109366 MW; F711F54634418ACF CRC64;
MLIFTPTTTS DSDLDSRKMK LVYFSNEFPR DDLQNFNDKH HSHLAQFICE ATWAIKEEAR
NLPTELKKLI PPFKTLVSWS ENTEIREGLI CGAVDGVLLV VVQIATYIGY AENSPEELTD
FPNLNLAGLG IGLLASTAVS LSSTLADLPL AGADAVRLAF RLGIHVLDVS ENLEARDLSE
SPDTWAYVVH NIDPDIVRKE LDTLYLRDEI PGTGKIFVSA VSRTSVTVSG PPARLKALFN
KSDFFRESTF IALPVYGGLC HAPHIYDMHD TQSIVDQNSL LTVRTKSWPG APIYSTSTSV
TYPAKKDTEL FESVISEILT QAIYWDRVIS GVVERVKTTV TSEVALYSFG NSIPLNDLNS
ALKSSITHSN VSISNLTTFV TQVAPKDTTP RSTSQSKLAI VGMSCRLPGG ATNTEKGLDV
SRKIPADRFD IETHYDPAEK ELNKTMTQYG CFIGEPGLFD APFFNISPRE SQVTDSQMRL
VLITAYEALE RAGYIGNCTA STQLQRIGTF YGQAADDYRE INQGQEVSTY YIPGGCGVLG
PGRINYFFKF AGPSYSIDTA CSSGLAAIEV TCQALWNGEV DTAVTGGVNV LTNPDGFSGL
CNGHFLTKGY NACKTWDTTT DGYCRADGIG SLAIKRLEDA EADNDNILGV ILGAGTNHSA
EAVSITHPHA GHQAYLSRQV LRQAGVDPLD VSYIEIHGTG IQAGDHEEMQ GIMDVYAPLT
RRRSKDQPLK YWRRKSKSLI KVLLMLQKNA VPPHIGIKTE INPKFEIDPR KTHIIAISAK
VKTSLTGNID RLIGYLDSHP NTNSADLSYT TTARRYHHTH RVAIATSDVA HLKRQLSSSL
DKVDLINPVG MSGPPLVAFS FTGQGASYKS MSLELYRGVP TFRKHIQYLE SLGQGQGFPS
FIAALDASYP NEHAHSAVIT QLALVCTEIA LAKHWATLGV KPDVVLGHSL GEYAAIHTAG
VITASDAIFM VGRRAQMLEE KCKVGSYIMM AVRASVAEIV ES
//
