ID B8MM59_TALSN Unreviewed; 2528 AA.
AC B8MM59;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Polyketide synthase, putative {ECO:0000313|EMBL:EED13571.1};
DE EC=2.3.1.161 {ECO:0000313|EMBL:EED13571.1};
GN ORFNames=TSTA_098280 {ECO:0000313|EMBL:EED13571.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED13571.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- PATHWAY: Secondary metabolite biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005179}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EQ962658; EED13571.1; -; Genomic_DNA.
DR RefSeq; XP_002485809.1; XM_002485764.1.
DR STRING; 441959.B8MM59; -.
DR GeneID; 8108467; -.
DR VEuPathDB; FungiDB:TSTA_098280; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_5_1; -.
DR InParanoid; B8MM59; -.
DR OMA; RNWIGAY; -.
DR OrthoDB; 5396558at2759; -.
DR PhylomeDB; B8MM59; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0050637; F:lovastatin nonaketide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000313|EMBL:EED13571.1};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EED13571.1}.
FT DOMAIN 32..457
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2445..2522
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2528 AA; 277252 MW; 8DCF94EDE275D67B CRC64;
MGDSGSSKPS EWTQVNGSHT SDEMISNEAG SVEPIAIVGV SCRLPGGASS PSKLWDLLEA
GKSAWGPFPS NRFSHSGFHS PFGLKNGTTN TNGGHFLEDD IAAFDAAFFG IRPMEATAID
PQQRLLLEVA YEAFENAGIT SEQVWGSNTG VYVGQWTSDY NEVLSRDTNF PAFYQTTGTG
PAISSNRLSY YFNMKGPSFT VDTGCSASMV ALHSAVQSLR TGETDRSFVA GVNLTLDPQR
YTYQSQLKMF SKEGKSFPFD ERANGYGRGE GCTGVVLQTL SSALKEGKPI RAIIRNSVLN
QDGRTPGISV PSGLAQSAAI RKAYAQAGIN LLDVDYVEAH GTGTKVGDPI EAKAIADALS
SSRDEENPLL IGSVKGNVGH LESAAGLTGL LKGLLMLEKC LVPPQVNFER ANTTIPLKQL
KLRVSTYDEQ LPLRDLRRIS INCFGYGGTN AHVILDSVDS FFAPPSPLTG RIKAPSKPEK
SARSRIFILS AETEKSVQVS AQKMAEYLKS KSGYTVNADI WLNNLAYTLG RRSLFGHRAG
VVASAVDELI VQLEDLSQQA VPRRDTKGQR RIGFVFSGQG AQYAGMGKEL LGNFPAFSNS
LERAGKCLTD IGCSWDLISE LLKPAEETRV DEPEVAQPLS TAIQLALADT LAELGIFPSF
VAGHSSGEIA AAYCAKAISF DDAMTVSYHR GRLASTLRKR VSDHPGGMLA VGESPEVVAA
KIKEIGEAQT RLRIACFNSP SSVTVSGDDD AILLLQEVLS GADIFNRKLR TGGAAYHSHQ
MDLIESEYRK ALDGIKGGKT DVSIVMVSSL TGEDIGDTVI DKDYWVQNLV SPVKFTEATR
KLCQTWSGQK RLDLLLELGP HFQLGGPISQ TLRTLRGDSA KIPYTGTLKR GTNAETTIFS
ALRTLFLEGF PVKLDLVNNG FDSTTANKLV TDVPSYSFDH SRTFWHESRI SKAYRYRKNI
PHDLLGTMGG DYNSVEPRWR KFIRLDDLPW LRGHIVQGQV VFPAAGYLAM AIQAMKEQIL
DENPDASIKN YKLRNVSFGM ALVLSEGIEN LELNFSLRPQ VHSARKSSKT WNEFRVFTVT
ADNSWTEHCR GLVHVELASE GDMNRVISAQ DQDLHAQLLQ FGKYINPKKL YFLAKDLGLD
WVSPFDNVID VKTTNGAAIS TVKPSDQDAT PYLIHPAVLD ACLFHSLYAV LIFEDNFKET
VVPTFIKTLN VAGNLGDLST KNLTCFARRT TGQLTYDIGI FDKEVEPATV FLQASTVTAT
RLPGLVPVEE GSRDLIHSIE WVTYMQSLTK NQIKRFKEGL EKVDSVMDRN NRLDALAMSY
IQQALKEVSP EEVGEGHLKH WYAWMRTHAY DSFDTTVLAE AMMDETIGGQ ALRRLGPHLP
DILRGNAHPL SFMREDGLLE KVYLEERCIR CYDQIAAYCA EFGRQAPDMK ILEIGAGTAS
VTLPLLEKIK SDDRVLASRY DFTDISAGFF PAAKERLAEY ENVVNYQVLN AENDPVEQGF
SANSYDIVVA CNVIHATSNI ETVLKNVRSL LRPGGKFILM EITLNQLYYN MFYGAFSGWW
SGYDEGRTMS PLLSIPQWKD KLYKTGFEQT EPMFNDYERK DGGTISVFVA HANETHKSEA
VNSAVDIVGL SPDDNVAGRL SKTLKELLSN QDILPTNLQA LGQSDTVSIF LPEVCDLLAG
SLDEEQWKSL KERITTSRAA LFITQARLSE STRPDGTVIN GFLRSLRMEH HEIRLISLEI
SAEGTVDSVA DVIAEVLCSP SFDLDAVAGD VESEYRERDG QLYVPRVIAQ REMSKFVHSS
LGKSQPTGSS FLGHNRVLTA ELAIPGLLET VRWRDDPEAI GPLDPDHIKI RLGAASINFK
DVLIASGQLE GINQMQNDCS GTVVEVGANM RNRYKPGDRV CALYSRSYTN YPIVHGDCCH
LIPDTLSIEE AASLPIVWIT VYYSIIDMGK LKKGESVLIH SGAGAVGQAA IMLAKYLGAK
IFVTVGSDAK KEFLMEKFGI PEDHFFSSRN TSFYEEIMQI TGGHGVDVVL NSLSGEMFRE
STNVVAPFGR FVEIGRKDLM DDALMPMEFL LKNVTFSYVD MALVIAKAKT LAQRVLHDVI
ELIIAGAISP VSIMTMPISK LEDAFRLIQA GKHIGKVILT VSEDQRVKII PPRPELAKLK
QDATYIVVGG LGGLGKQIVK WMAERGAKNI VTFSRSGTLN EQTLALIDSV KELGTTVYVK
KCDVGDMDQL RRVMAELKDN LPPIRGIVQS AMILEDSVFD EMTFKHWLDA VNPKVEGTWN
LHKALPSNLD FFIMLSSAVA VAGNVGQSNY SAACAFQDAL AHYRTSRGLR AHSINVGAIV
EIGYVSENPE VAASLRRQGM GTTSVYEFLA HLDQVISNPI ACQPGHCQTS IGLVPSGDEL
GLGESVWMED MKFTHVRRQG SSQIQISGAT SDVITELRSV GTPEDAVEVI CQAILIQLSK
VTALPAERLS RGESLDTYGV DSLVAVELRN WIGAYLQANV PLLVLRGTGS IQELAEMSPK
SPGSWRIP
//