ID B8MP98_TALSN Unreviewed; 247 AA.
AC B8MP98;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=TSTA_105480 {ECO:0000313|EMBL:EED14337.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED14337.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
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DR EMBL; EQ962658; EED14337.1; -; Genomic_DNA.
DR RefSeq; XP_002486575.1; XM_002486530.1.
DR AlphaFoldDB; B8MP98; -.
DR STRING; 441959.B8MP98; -.
DR GeneID; 8100407; -.
DR VEuPathDB; FungiDB:TSTA_105480; -.
DR eggNOG; ENOG502QTD3; Eukaryota.
DR HOGENOM; CLU_070319_0_0_1; -.
DR InParanoid; B8MP98; -.
DR OMA; RNEGAVM; -.
DR OrthoDB; 2049468at2759; -.
DR PhylomeDB; B8MP98; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0019172; F:glyoxalase III activity; IEA:UniProt.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF22; DJ-1_PFPI DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001745}.
FT DOMAIN 100..238
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 247 AA; 26986 MW; 5A4659FB66B61AFE CRC64;
MAPKKVLIVL SDAHSFPLKK PASSSNDKDQ IVQQPSGFFL MELAKPLAQL LESGAPNPLQ
TPTVETLLAF AGNFYERRHE NELIDRMRRE NGFDSPRPFK SISDEELDSF AGVFIPGGHA
PLQDLGDDPE LGRILKHFHN KTKPTAAICH GPYAFLSTKA TSPGEFAYKG YKLTSWSDAE
ERMMETMLGG EIEKVESSLK DSGAEMVAGA REKAGYITVD KEVVSGGNPL AADALGKQFL
KMLSEKA
//
