ID   B8MQI0_TALSN            Unreviewed;       524 AA.
AC   B8MQI0;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Acetyl-CoA hydrolase {ECO:0000256|ARBA:ARBA00017958};
DE            EC=3.1.2.1 {ECO:0000256|ARBA:ARBA00011920};
DE   AltName: Full=Acetyl-CoA deacylase {ECO:0000256|ARBA:ARBA00029672};
GN   ORFNames=TSTA_058710 {ECO:0000313|EMBL:EED13382.1};
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS   1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441959 {ECO:0000313|EMBL:EED13382.1, ECO:0000313|Proteomes:UP000001745};
RN   [1] {ECO:0000313|Proteomes:UP000001745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC   {ECO:0000313|Proteomes:UP000001745};
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O = acetate + CoA + H(+); Xref=Rhea:RHEA:20289,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=3.1.2.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001831};
CC   -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family.
CC       {ECO:0000256|ARBA:ARBA00009632}.
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DR   EMBL; EQ962659; EED13382.1; -; Genomic_DNA.
DR   RefSeq; XP_002487493.1; XM_002487448.1.
DR   AlphaFoldDB; B8MQI0; -.
DR   STRING; 441959.B8MQI0; -.
DR   GeneID; 8106473; -.
DR   VEuPathDB; FungiDB:TSTA_058710; -.
DR   eggNOG; KOG2828; Eukaryota.
DR   HOGENOM; CLU_019748_3_0_1; -.
DR   InParanoid; B8MQI0; -.
DR   OMA; DEALSWH; -.
DR   OrthoDB; 100792at2759; -.
DR   PhylomeDB; B8MQI0; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0008775; F:acetate CoA-transferase activity; IEA:InterPro.
DR   GO; GO:0003986; F:acetyl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006083; P:acetate metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.750.70; 4-hydroxybutyrate coenzyme like domains; 1.
DR   Gene3D; 3.40.1080.20; Acetyl-CoA hydrolase/transferase C-terminal domain; 1.
DR   Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR   InterPro; IPR026888; AcetylCoA_hyd_C.
DR   InterPro; IPR038460; AcetylCoA_hyd_C_sf.
DR   InterPro; IPR046433; ActCoA_hydro.
DR   InterPro; IPR003702; ActCoA_hydro_N.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR43609; ACETYL-COA HYDROLASE; 1.
DR   PANTHER; PTHR43609:SF1; ACETYL-COA HYDROLASE; 1.
DR   Pfam; PF13336; AcetylCoA_hyd_C; 1.
DR   Pfam; PF02550; AcetylCoA_hydro; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:EED13382.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001745}.
FT   DOMAIN          14..230
FT                   /note="Acetyl-CoA hydrolase/transferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02550"
FT   DOMAIN          332..482
FT                   /note="Acetyl-CoA hydrolase/transferase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13336"
SQ   SEQUENCE   524 AA;  58124 MW;  7419D6A6DCCB0D2B CRC64;
     MAASALLKSR VRRPSYLNKL AKAEDLIDLF PHGSYIGWSG FTGVGYPKKV PTALADHVEK
     NNLQGKLKYS LFVGASSGAE TENRWARLNM IERRSPHQVG KEIAKGINTG NIQFFDKHLS
     MFPSDLVYGW YTKDRPHNKL DVTVVEATAI TEDGGIIPGA SVGASPELVQ MADKIIIEVN
     TATPSFEGLH DISLSDLPPR RKPYLILSPE DRIGTPHIPV DPEKVVAIVE SDYPDATMPN
     APEDESSRAI ARNLIEFLQH EVKHGRLPEN LLPIQSGIGN IANAVIGGLS HGANFKNLKV
     WTEVLQDSFL DLFDSGHLDF ATATSIRFSP DGFKRFYDGW ERYSPKLLLR SQQVSNSPEI
     IRRLGVIGMN TPVEVDIYAH ANSTCVMGSR MLNGLGGSAD FLRSAKYSIM HTPSTRPTKT
     DPTGVSCIVP MCTHVDQTEH DLDVVVTEQG LADVRGLSPR ERARVIIDKC SHPDYKPILQ
     DYFDRAEFEC LKKGMGHEPH MLFKAFNMHK NLAENGTMKI KSWD
//