ID B8MR42_TALSN Unreviewed; 493 AA.
AC B8MR42;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=poly(A)-specific ribonuclease {ECO:0000256|ARBA:ARBA00012161};
DE EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
GN ORFNames=TSTA_054490 {ECO:0000313|EMBL:EED12937.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED12937.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001663};
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR EMBL; EQ962659; EED12937.1; -; Genomic_DNA.
DR RefSeq; XP_002487048.1; XM_002487003.1.
DR AlphaFoldDB; B8MR42; -.
DR STRING; 441959.B8MR42; -.
DR GeneID; 8100387; -.
DR VEuPathDB; FungiDB:TSTA_054490; -.
DR eggNOG; KOG0304; Eukaryota.
DR HOGENOM; CLU_027974_3_0_1; -.
DR InParanoid; B8MR42; -.
DR OMA; QMRDRIF; -.
DR OrthoDB; 341493at2759; -.
DR PhylomeDB; B8MR42; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProt.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR039637; CNOT7/CNOT8/Pop2.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10797; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT; 1.
DR PANTHER; PTHR10797:SF0; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 7; 1.
DR Pfam; PF04857; CAF1; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT REGION 21..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 53293 MW; CCD9B5B43C93072D CRC64;
MPPPIGRYGP SALNTPFGHL QQAHQLQQQQ TQQQSQSQHH ATHTQAALPP PSLGGHPGFS
AVASSSTANP FGLASTNGVG AFSADIANGT GLASHAAQMG FVRGAQMQQQ QLHQAQDGRL
LLESKANPIK TRIRDVWKHN LAQEMAVLRR LVERYPYISM DTEFPGIVAR PMGAFTTKAD
YHYQTLRCNV DLLKMIQLGV TLFSPEGELP PATPTEVNGQ GYASNYGPAP CTWQFNFRFS
LEDDMYAQDS TSMLAKAGID FSMHEKNGID PVEFGALLMS SGLVLLDDVH WISFHSGYDF
GYLMKIMLCK PLPEDEEEFH KLLKIFFPSL YDIKYLMKHA GRNQTANDSP LTPAALQVIN
NLGQKSGLQD IADELGVKRV GIAHQAGSDS LVTGEIYWKM RQIVFNGTID EAKYSGQVWG
LNGQLPAMTT YYAQQTPNLN GATIYSTAGT PSTPNNTSTN AGGSSQTPSH IGAGALTPGG
GGGVFGAFQM GKS
//
