ID B8MWT5_ASPFN Unreviewed; 1072 AA.
AC B8MWT5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 03-MAY-2023, entry version 77.
DE SubName: Full=Exportin KapK {ECO:0000313|EMBL:EED58186.1};
GN ORFNames=AFLA_088850 {ECO:0000313|EMBL:EED58186.1}, G4B84_000600
GN {ECO:0000313|EMBL:QMW25355.1};
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952 {ECO:0000313|EMBL:EED58186.1, ECO:0000313|Proteomes:UP000001875};
RN [1] {ECO:0000313|EMBL:EED58186.1, ECO:0000313|Proteomes:UP000001875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC SRRC 167 {ECO:0000313|Proteomes:UP000001875}, and NRRL3357
RC {ECO:0000313|EMBL:EED58186.1};
RX PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
RN [2] {ECO:0000313|EMBL:QMW25355.1, ECO:0000313|Proteomes:UP000515286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL3357 {ECO:0000313|EMBL:QMW25355.1,
RC ECO:0000313|Proteomes:UP000515286};
RA Fountain J.C., Clevenger J.P., Nadon B., Youngblood R.C., Korani W.,
RA Chang P.-K., Starr D., Wang H., Isett B., Johnston H.R., Wiggins R.,
RA Chu Y., Agarwal G., Kemerait R.C., Pandey M.K., Bhatnagar D.,
RA Ozias-Akins P., Varshney R.K., Scheffler B.E., Vaughn J.N., Guo B.;
RT "Two New Chromosome-Level Aspergillus flavus Reference Genomes Reveal a
RT Large Insertion Potentially Contributing to Isolate Stress Tolerance and
RT Aflatoxin Production.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease. {ECO:0000256|ARBA:ARBA00025147}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EQ963472; EED58186.1; -; Genomic_DNA.
DR EMBL; CP059866; QMW25355.1; -; Genomic_DNA.
DR RefSeq; XP_002373798.1; XM_002373757.1.
DR AlphaFoldDB; B8MWT5; -.
DR STRING; 332952.B8MWT5; -.
DR EnsemblFungi; EED58186; EED58186; AFLA_088850.
DR VEuPathDB; FungiDB:AFLA_004485; -.
DR eggNOG; KOG2020; Eukaryota.
DR HOGENOM; CLU_011906_0_0_1; -.
DR OMA; WAFKHNN; -.
DR OrthoDB; 169519at2759; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR Proteomes; UP000515286; Chromosome 1.
DR GO; GO:0000776; C:kinetochore; IEA:EnsemblFungi.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0005816; C:spindle pole body; IEA:EnsemblFungi.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IEA:EnsemblFungi.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:EnsemblFungi.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030619; F:U1 snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0030620; F:U2 snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0030621; F:U4 snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0030623; F:U5 snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0017070; F:U6 snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0006611; P:protein export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0034501; P:protein localization to kinetochore; IEA:EnsemblFungi.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR041123; CRM1_repeat.
DR InterPro; IPR041235; Exp1_repeat_2.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR045065; XPO1/5.
DR InterPro; IPR014877; XPO1_C_dom.
DR InterPro; IPR040485; XPO1_repeat_3.
DR PANTHER; PTHR11223; EXPORTIN 1/5; 1.
DR PANTHER; PTHR11223:SF2; EXPORTIN-1; 1.
DR Pfam; PF08767; CRM1_C; 1.
DR Pfam; PF18777; CRM1_repeat; 1.
DR Pfam; PF18784; CRM1_repeat_2; 1.
DR Pfam; PF18787; CRM1_repeat_3; 1.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM01102; CRM1_C; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 26..92
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 1072 AA; 123329 MW; BD8AD0CF51E03844 CRC64;
MSVSIQELDN TVQAFYEGKG DLQKQAQQTL TEFKQNPDAW LIVGNILQES SYPQTKYLAL
QVLDDVIMTR WKVLPREQCL GIRNFIVNFI IENSSSEEKL RSERAFLNKL NLVLVSILKQ
EWPHNWPTFI NEIISSCHTS LSICENNMAI LRLLSEEVFD FSQDQMTSVK ARNLKTSMTQ
EFSSIFQLCS EVLNTANQPS LIKATLETLL RFLNWIPLGY IFETPIISTL LTRFLDVPEF
RNVTLKCLTE IGGLQIGNPY NYDERLVHMF TETLTVVSKI IPLSMDLKQT YAKSNSRDQE
FVLNLALFLS SFFSAHLNLI EKLPNRDYLT HAHFYLIRIS QIDDREVFKI CLEYWTRLVQ
ELYEEMQQLP ITDINPLVSM GVSGLSNGGA PHPSTLANYP LRKHKYEEVL SSLRTVMIEK
MVRPEEVLIV ENDEGEIVRE FVKESDTIQL YKTIRECLVY LTHLDVVDTE NIMIEKLAKQ
VDGSEWSWAN CNTLCWAIGS ISGAMNEETE KRFLVTVIKD LLGLTEMKRG KDNKAVVASN
IMYIVGQYPR FLKAHWKFLK TVVNKLFEFM HETHEGVQDM ACDTFIKIAN KCRRHFVALQ
PGENEPFIEE IVRSMRKITC DLSPQQVHTF YEACGYMISA QGQKGLQDRL IENLMSLPNS
AWDAIIGQAN QDPSILQDGE TIKIIGNIMK TNVAACSSIG TYFYSQLGRI YHDMLNMFRA
SSQLISDAVV RDGEIATKTP KVRGLRTIKK EILKLIDTYV QKADDLEMVN ANMVPPLLEA
VLVDYNRNVP DAREAEVLNV MTTIIHKLHN LMEDKVPLIM ESVFECTLEM INKDFHEYPE
HRVQFFKLLQ AINLYCFPAL LKLDATQFKF VIDSCMWASK HDNREVENTG LTMCLELMNN
MAETDTQTSN IFFRQFYIPI LQDVFFVLTD SDHKAGFKSQ AMLLSRMFYF VEAGKVQDPI
YSPEQAPLGT SNKDFLQEYV ANLLQNAFKN LQEIQIKQFV IGLFAFNDDF NKFKTHLRDF
LISLKEFAGD NAELYAEERE QALRDAKAAE RDRAMKVGGL LKPSEMDQED EL
//
