ID B8NCW1_ASPFN Unreviewed; 453 AA.
AC B8NCW1;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 13-SEP-2023, entry version 66.
DE SubName: Full=Cation diffusion facilitator 1 {ECO:0000313|EMBL:EED52494.1};
GN ORFNames=AFLA_041960 {ECO:0000313|EMBL:EED52494.1}, G4B84_010596
GN {ECO:0000313|EMBL:QMW35105.1};
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952 {ECO:0000313|EMBL:EED52494.1, ECO:0000313|Proteomes:UP000001875};
RN [1] {ECO:0000313|EMBL:EED52494.1, ECO:0000313|Proteomes:UP000001875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC SRRC 167 {ECO:0000313|Proteomes:UP000001875}, and NRRL3357
RC {ECO:0000313|EMBL:EED52494.1};
RX PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
RN [2] {ECO:0000313|EMBL:QMW35105.1, ECO:0000313|Proteomes:UP000515286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL3357 {ECO:0000313|EMBL:QMW35105.1,
RC ECO:0000313|Proteomes:UP000515286};
RA Fountain J.C., Clevenger J.P., Nadon B., Youngblood R.C., Korani W.,
RA Chang P.-K., Starr D., Wang H., Isett B., Johnston H.R., Wiggins R.,
RA Chu Y., Agarwal G., Kemerait R.C., Pandey M.K., Bhatnagar D.,
RA Ozias-Akins P., Varshney R.K., Scheffler B.E., Vaughn J.N., Guo B.;
RT "Two New Chromosome-Level Aspergillus flavus Reference Genomes Reveal a
RT Large Insertion Potentially Contributing to Isolate Stress Tolerance and
RT Aflatoxin Production.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; EQ963476; EED52494.1; -; Genomic_DNA.
DR EMBL; CP059872; QMW35105.1; -; Genomic_DNA.
DR RefSeq; XP_002377658.1; XM_002377617.1.
DR AlphaFoldDB; B8NCW1; -.
DR STRING; 332952.B8NCW1; -.
DR EnsemblFungi; EED52494; EED52494; AFLA_041960.
DR VEuPathDB; FungiDB:AFLA_007759; -.
DR eggNOG; KOG1485; Eukaryota.
DR HOGENOM; CLU_013430_2_2_1; -.
DR OMA; CWALRNQ; -.
DR OrthoDB; 5479358at2759; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR Proteomes; UP000515286; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0098771; P:inorganic ion homeostasis; IEA:UniProt.
DR GO; GO:0030003; P:intracellular monoatomic cation homeostasis; IEA:UniProt.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR Gene3D; 3.30.70.1350; Cation efflux protein, cytoplasmic domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027470; Cation_efflux_CTD.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR43840:SF12; CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440); 1.
DR PANTHER; PTHR43840; MITOCHONDRIAL METAL TRANSPORTER 1-RELATED; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR Pfam; PF16916; ZT_dimer; 1.
DR SUPFAM; SSF160240; Cation efflux protein cytoplasmic domain-like; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 162..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 367..438
FT /note="Cation efflux protein cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF16916"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 50890 MW; 6A5CD8FB67206880 CRC64;
MDESHLRQSM SHHPSPFNSP QPPHSHIPST LSYNEATTTA LEPQASQHRT GNTSDEEGQP
PPRYTRENDP FQLASKIKTD EEIRQIHPQA NTARKRDSCG PGGLLRATKN PKKALDTAIS
SRQLQGFYHS QNENIERMLK PVEEHVRDAR EISVNNQLKY KIAVYGSFAA NVILSVLQLY
GAIASGSLSL FTTMADAVFD PMSNLTLLLC NKAVNRVDPR KFPAGKARIE TAGNICFCFL
MTAVSFIIIA FSIRELVEGS QSETSDFHLP SVVAVIVAFC TKFALFVYCF ALRHQVSQIR
ILWEDHRNDL FINGFGILTS VGGSKLRWWI DPMGAIILSV LVSCLWLYTA YHEFQLLIGV
TADTKMQQLI TYISMTHSPF ITAIDTVRAY TSGPRLLVEV DVVMDPNDSL RATHDVAEEL
QMKLESLPDV ERAYVHVDYE TTHKPEHFLK KEL
//
