ID   B8NDK8_ASPFN            Unreviewed;       757 AA.
AC   B8NDK8;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=LipA and NB-ARC domain protein {ECO:0000313|EMBL:EED51684.1};
GN   ORFNames=AFLA_059470 {ECO:0000313|EMBL:EED51684.1};
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS   / JCM 12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=332952 {ECO:0000313|EMBL:EED51684.1, ECO:0000313|Proteomes:UP000001875};
RN   [1] {ECO:0000313|EMBL:EED51684.1, ECO:0000313|Proteomes:UP000001875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC   SRRC 167 {ECO:0000313|Proteomes:UP000001875};
RX   PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC   -!- SIMILARITY: Belongs to the putative lipase ROG1 family.
CC       {ECO:0000256|ARBA:ARBA00007920}.
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DR   EMBL; EQ963477; EED51684.1; -; Genomic_DNA.
DR   RefSeq; XP_002378691.1; XM_002378650.1.
DR   AlphaFoldDB; B8NDK8; -.
DR   EnsemblFungi; EED51684; EED51684; AFLA_059470.
DR   VEuPathDB; FungiDB:AFLA_005003; -.
DR   eggNOG; KOG2029; Eukaryota.
DR   HOGENOM; CLU_010646_0_0_1; -.
DR   OMA; WKWDDAR; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007751; DUF676_lipase-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR48182; PROTEIN SERAC1; 1.
DR   PANTHER; PTHR48182:SF2; PROTEIN SERAC1; 1.
DR   Pfam; PF05057; DUF676; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          134..195
FT                   /note="DUF676"
FT                   /evidence="ECO:0000259|Pfam:PF05057"
FT   REGION          316..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..338
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   757 AA;  84786 MW;  240E25F2E7DFF8DA CRC64;
     MGYGLCQGLT NHIGPLRIEF RLVCSIGYEG PIRSRYRRHL PSRIIPAASF VFVHGLNPRG
     RVDHAFETWT HQNGTFWPRD YLPQDIPQAR VFVYGYNSYV TNPQVMSNAS VKDHANTLLN
     LLDLERSPQV NARPPKIIFI GHSLGGLVIK QALLNAQEDP KYTSIRTGTY GLVFFGTPHH
     GTKGVELGKI AAKVAKFVSK GHASNDLLDC LEHNSLFTRQ MSSRFCHQLE DYRVISFIEG
     KEVLLGGSGP ASISHLVVDE ESAILGLPGN RETRLKLDAD HSQMCKVGTR GAMYKLIKGN
     IKQIADQLLV TEQGYITQPS PSPRAGPPLP PRHTNSSAPY PPPNITSQAA TQRVIGTLYH
     PFDNDPRSIE AAEYKNNWKW DDARRVEYTI FQEHLRTLGA DHHSTLQVGY NLAEIDLESG
     YLGKAAEWCQ WVSNNSQRVL DKRHPLTMRA ESLMGEILVS QGKQQEGESV CANVLARQQM
     TIGEDDIDTL ETRRRLANAY SSVERREEGI ATAEKRTESL KRLLGENHIK TYAAVLDTIE
     LIVAKLSSSN EAMAIARFHT GTEDIVNVVQ EASREMNNLL GPRHPLSIRS LRLLGACQIF
     TSGGLTEPSE TLRRALATAE ENLGSDNPET IQIVVYMGLM YAKQSNPYSY LVSQQNLELA
     MPWFRRYLDW AKSRDILSSP DPQAILGMIA NMYMGKRDYQ QAQNYYEQLV TACQKGNIPV
     PADVQNMLQL CRMNTRLMSP YTSSSGFESL LSSFKRL
//