ID B8NF73_ASPFN Unreviewed; 1766 AA.
AC B8NF73;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Rho guanyl nucleotide exchange factor, putative {ECO:0000313|EMBL:EED51854.1};
GN ORFNames=AFLA_061170 {ECO:0000313|EMBL:EED51854.1}, G4B84_007663
GN {ECO:0000313|EMBL:QMW32232.1};
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952 {ECO:0000313|EMBL:EED51854.1, ECO:0000313|Proteomes:UP000001875};
RN [1] {ECO:0000313|EMBL:EED51854.1, ECO:0000313|Proteomes:UP000001875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC SRRC 167 {ECO:0000313|Proteomes:UP000001875}, and NRRL3357
RC {ECO:0000313|EMBL:EED51854.1};
RX PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
RN [2] {ECO:0000313|EMBL:QMW32232.1, ECO:0000313|Proteomes:UP000515286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL3357 {ECO:0000313|EMBL:QMW32232.1,
RC ECO:0000313|Proteomes:UP000515286};
RA Fountain J.C., Clevenger J.P., Nadon B., Youngblood R.C., Korani W.,
RA Chang P.-K., Starr D., Wang H., Isett B., Johnston H.R., Wiggins R.,
RA Chu Y., Agarwal G., Kemerait R.C., Pandey M.K., Bhatnagar D.,
RA Ozias-Akins P., Varshney R.K., Scheffler B.E., Vaughn J.N., Guo B.;
RT "Two New Chromosome-Level Aspergillus flavus Reference Genomes Reveal a
RT Large Insertion Potentially Contributing to Isolate Stress Tolerance and
RT Aflatoxin Production.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; EQ963477; EED51854.1; -; Genomic_DNA.
DR EMBL; CP059870; QMW32232.1; -; Genomic_DNA.
DR RefSeq; XP_002378861.1; XM_002378820.1.
DR STRING; 332952.B8NF73; -.
DR EnsemblFungi; EED51854; EED51854; AFLA_061170.
DR VEuPathDB; FungiDB:AFLA_005169; -.
DR eggNOG; KOG4305; Eukaryota.
DR HOGENOM; CLU_001083_0_0_1; -.
DR OMA; DMFYHPG; -.
DR OrthoDB; 2734900at2759; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR Proteomes; UP000515286; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 949..1141
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1178..1330
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1395..1706
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..224
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..347
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1766 AA; 194621 MW; 379846501253FD25 CRC64;
MAHYQNGQPP YGQSGNSAQP SRYDLYTSAS SNSQHNPTLR RMPSYSIGDD AGLFAPSHSH
NPRPTDASAR YSEWGAGDSQ GGYSNDGQEY AEHPRYAHLP SATSSQIPRS RASSQSSYQY
QYTSSIASPT QTAYNPQQYA VPSTPSQLNY NPLAYSSASS SSAPGYQPYN PAAYQTTTVA
GYSSAGVQRH PSVGYAQAPP TPLSYAPPVP SLPPPPPPRG PDHPYGSRLS PQYSSSTSPG
TPYGLAPTAS SYNLASPSTP SATYVSSFTG MGSAQSRPYS SGSYGPSSPR RSESAAAASH
EDQPPEPPAH ASSGDDPYGK RLSLTRPGSG RSLPTPPIYP PQPPVSPQRT DTLTRHPQSR
PLPGPPVDAE DDSAPLTNGG SLHGRPDGRA GYDDLLREVE AAVLDAGDRS SLRSLRLEAQ
NSNNGGDGLR LSPDEKHTHT NGNMATGTGQ YVNYDAYSDD SDAEAAAGLA MLQMADEEDR
MRAERLQERE RRETNASIIS AYASQQQAEA GDEAVRYGGN LRGQSQYEET DVSADEYADA
VDHGRLAPTS GSLRSSNMSA EDRGQYSDEY EYPPMTQDAE YPFELVPSYA RVDAAGTGGL
SEPSAYGRRM SFDYGDEGTL SPVRRSHQSG SDDSDRGEEP GDLFFHPGMR PLPPAPVEPA
NRADLIPHLM PAGTYRHQEQ EDWQSATQYT PSYYPVSADS YGPTVPSPSS QVPRSTSLSS
HPIGPRTDPP IRSKTDADRA KYKQQHELHR QSGSPKVASP QAAAAMTLDL PTIPAGRRKK
FNPTKLSTEQ FRRCAEPWAL SAILEWIREL SEEETDLKEH TIVDAIVALF THKVPTMNIA
DAETLAARVV QNMLAEEALI KEEEWVKFGN GSLSGVLFQI TGTGCYSSRL HEQETEVFGR
CYSHHCMRTL KKVNLRTQVM AQQKKAEDWV TFYKVPKELW ETYPKKEIDR QNNLHEIVTT
EDSFIGQLDI LRELYRDQLA SMQPSIIPPK RANKFLKDVF GKVDLVKKVN EDHLLAQLKY
RQKEQGPFIA GFSDIFRQWI RKAKAVYIDY AATFPHANYL VRSEAERNIQ FRQFLEQAQS
HKLSNRLSWD TYLKAPITRI QRYTLLLATV HKNMLKDSEE KANLAQAIEE IKLVALECDN
KVGETSKKVS LMELSAKLQL RPEMKREVEL NLEHLGREIV HQGILQRPGT RTRFLQETHA
ILFDHYLVLA KPVPKYKVFD VSKLPIPMDL LVVESTNEDP VVKSSVRGVA TVTQPQAVAT
RAVDGNGANA AGAAAGKTIV PTTVLESSTD NKILYPFKIK HLGKNGTYTL YASSAQSRQD
WCEKIIEAKT KHAAALFAQN AEPFRLRVLA DTAFASSDYS PPPKSVIIEG TPLDRAIKDV
EHRFGDLKRP APVCRASVHS ATVFQQPPGR MMCAIGTDNG VYISEYNDPR GWVRAIQIPR
VTQIAVFEEF NVFLLIADKS LIAYHLDVVC PPSGVPTPTT SDSARRAPQK ISGSREVGFF
AAGHMKDRTL VMYKKRDGLS STFKIMEPVL QKSSTSKSRF FSRRSQTEFF RDYDEFYIPA
ESYGINMFHS SLAISTQRGI EILTLDKKQT WSVPDFRSEA PEAQAQLTSI AARITNLRPL
GMFRLSDSEF LVVYAECAVY VNKHGDVSRS VVMEFVGRAH TACLYGKFLI LFNEDFVEVR
NAMNGRLRQV IPGHGVVCLD DGSSMPGSGA NSIPTTTGGT VNLSSGLSNG VALANNGRTV
KICMQHPEYE RNQIILELIE NEGQKD
//
