ID B8NJP4_ASPFN Unreviewed; 502 AA.
AC B8NJP4;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN ORFNames=AFLA_068540 {ECO:0000313|EMBL:EED50032.1}, G4B84_009856
GN {ECO:0000313|EMBL:QMW34390.1};
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952 {ECO:0000313|EMBL:EED50032.1, ECO:0000313|Proteomes:UP000001875};
RN [1] {ECO:0000313|EMBL:EED50032.1, ECO:0000313|Proteomes:UP000001875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC SRRC 167 {ECO:0000313|Proteomes:UP000001875}, and NRRL3357
RC {ECO:0000313|EMBL:EED50032.1};
RX PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
RN [2] {ECO:0000313|EMBL:QMW34390.1, ECO:0000313|Proteomes:UP000515286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL3357 {ECO:0000313|EMBL:QMW34390.1,
RC ECO:0000313|Proteomes:UP000515286};
RA Fountain J.C., Clevenger J.P., Nadon B., Youngblood R.C., Korani W.,
RA Chang P.-K., Starr D., Wang H., Isett B., Johnston H.R., Wiggins R.,
RA Chu Y., Agarwal G., Kemerait R.C., Pandey M.K., Bhatnagar D.,
RA Ozias-Akins P., Varshney R.K., Scheffler B.E., Vaughn J.N., Guo B.;
RT "Two New Chromosome-Level Aspergillus flavus Reference Genomes Reveal a
RT Large Insertion Potentially Contributing to Isolate Stress Tolerance and
RT Aflatoxin Production.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR EMBL; EQ963479; EED50032.1; -; Genomic_DNA.
DR EMBL; CP059871; QMW34390.1; -; Genomic_DNA.
DR RefSeq; XP_002380413.1; XM_002380372.1.
DR AlphaFoldDB; B8NJP4; -.
DR STRING; 332952.B8NJP4; -.
DR EnsemblFungi; EED50032; EED50032; AFLA_068540.
DR VEuPathDB; FungiDB:AFLA_008793; -.
DR eggNOG; KOG1116; Eukaryota.
DR HOGENOM; CLU_013399_0_1_1; -.
DR OMA; TMGNFYA; -.
DR OrthoDB; 374620at2759; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR Proteomes; UP000515286; Chromosome 6.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EED50032.1};
KW Transferase {ECO:0000313|EMBL:EED50032.1}.
FT DOMAIN 133..272
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 341..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 54247 MW; CDDE46585273BC1A CRC64;
MTSPSNGPSS NHADQPDSQR LLQHDSTLTV AQSVSLSIGG DSLLVVDERP KSKDQRACCG
LLAKSSKTTH SIGLYNILDA DLSPAGLTIT YAQAATKGSI SVAALEYPIS EKEKANAQTW
VSRLLDLAYG EAQRYKRLKV LINPFGGKGA ASKIYHKHAA PVFAAARCVV DVQQTTHRGH
ATEIVEQIDI DAYDAIVCCS GDGLPYEVFN GLGKKPNAGE ALAKVAVAMV PCGSGNAMAW
NLCGTGNVSV AALAIVKGLR TPMDLVSLTQ GNTRTLSFLS QSFGVIAESD LGTDNIRWMG
AHRFTYGFLV RIMQRTVYPC DLAIKVEIDD KRAIKDHYNT YAHNPAPRRS PEETAGQSKG
LPELRYGTVQ DDLPKDWEVV PGEEMGNFYA GKMAIVSKDT NFFPASVPND GLMDIVTING
TLPRTTTLKM MTAIPENEFF DMPDVKIRKA AAYRLVPRQK EGYISVDGES IPFEALQAEV
HKGLGTVLSK SGHLYEAEGP RP
//
