ID B8NKJ2_ASPFN Unreviewed; 497 AA.
AC B8NKJ2;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=3-phytase {ECO:0000256|ARBA:ARBA00012632};
DE EC=3.1.3.8 {ECO:0000256|ARBA:ARBA00012632};
GN ORFNames=AFLA_091580 {ECO:0000313|EMBL:EED49077.1}, G4B84_008458
GN {ECO:0000313|EMBL:QMW33027.1};
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952 {ECO:0000313|EMBL:EED49077.1, ECO:0000313|Proteomes:UP000001875};
RN [1] {ECO:0000313|EMBL:EED49077.1, ECO:0000313|Proteomes:UP000001875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC SRRC 167 {ECO:0000313|Proteomes:UP000001875}, and NRRL3357
RC {ECO:0000313|EMBL:EED49077.1};
RX PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
RN [2] {ECO:0000313|EMBL:QMW33027.1, ECO:0000313|Proteomes:UP000515286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL3357 {ECO:0000313|EMBL:QMW33027.1,
RC ECO:0000313|Proteomes:UP000515286};
RA Fountain J.C., Clevenger J.P., Nadon B., Youngblood R.C., Korani W.,
RA Chang P.-K., Starr D., Wang H., Isett B., Johnston H.R., Wiggins R.,
RA Chu Y., Agarwal G., Kemerait R.C., Pandey M.K., Bhatnagar D.,
RA Ozias-Akins P., Varshney R.K., Scheffler B.E., Vaughn J.N., Guo B.;
RT "Two New Chromosome-Level Aspergillus flavus Reference Genomes Reveal a
RT Large Insertion Potentially Contributing to Isolate Stress Tolerance and
RT Aflatoxin Production.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR EMBL; EQ963480; EED49077.1; -; Genomic_DNA.
DR EMBL; CP059870; QMW33027.1; -; Genomic_DNA.
DR RefSeq; XP_002380978.1; XM_002380937.1.
DR AlphaFoldDB; B8NKJ2; -.
DR STRING; 332952.B8NKJ2; -.
DR EnsemblFungi; EED49077; EED49077; AFLA_091580.
DR VEuPathDB; FungiDB:AFLA_009387; -.
DR eggNOG; KOG1382; Eukaryota.
DR HOGENOM; CLU_020880_3_1_1; -.
DR OMA; RGRSDWC; -.
DR OrthoDB; 2404758at2759; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR Proteomes; UP000515286; Chromosome 5.
DR GO; GO:0016158; F:3-phytase activity; IEA:UniProtKB-EC.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR016274; Histidine_acid_Pase_euk.
DR PANTHER; PTHR20963:SF18; ACID PHOSPHATASE PHO11-RELATED; 1.
DR PANTHER; PTHR20963; MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR PIRSF; PIRSF000894; Acid_phosphatase; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR000894-2};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..497
FT /note="3-phytase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035142744"
FT ACT_SITE 101
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000894-1"
FT ACT_SITE 370
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000894-1"
FT DISULFID 90..422
FT /evidence="ECO:0000256|PIRSR:PIRSR000894-2"
FT DISULFID 296..309
FT /evidence="ECO:0000256|PIRSR:PIRSR000894-2"
FT DISULFID 451..459
FT /evidence="ECO:0000256|PIRSR:PIRSR000894-2"
SQ SEQUENCE 497 AA; 55747 MW; 8E265D919F350936 CRC64;
MLNVTSPWAL ILSLLTAIVS ISYYDNNPSA PEIRSPHCAS WNAWYNPLRS GQVGYQANDW
NILYHLGGNG PWIEKIDELE TPGLEPPKGC VIDQVHMISR HGERYPTKSA GSRHLALLNR
IKEANVVLNG SLSFLNNWTY FTDEPQKDFD QLTRTSPYAG TLQAFSTGIR FLTRYGHLLP
LHGTTRLWAS ECNRVIETAQ HFASGFFGLD WEKTEKAALE IIPETLERGA DTLTPGDTCP
KYIEDPAKGH DNGVNMLALF QDVYIPAIAE RLINDENNSA LGYLTNLEVY GMQEMCGFET
LSRGSSPWCD IFTHDDWENF EYARDLIHYY RAGPGNPYAG AMGWLWLNAT TGLLRSGPEA
GTMFFSFVHD GDIAPLVTAM EILKDPKYDP FLPTTHRVED RVWRTSSVMP MGGRIVFERL
TCPTSSAKDP SGEEAFLRVN INDKIVPLPY CKSGPGLSCP LKEFVDHVER RRSEVGDFGE
VCGLEKDVGY ITFLRQG
//