ID B8NVY3_ASPFN Unreviewed; 1043 AA.
AC B8NVY3;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=NRPS-like enzyme, putative {ECO:0000313|EMBL:EED45682.1};
GN ORFNames=AFLA_119110 {ECO:0000313|EMBL:EED45682.1}, G4B84_011981
GN {ECO:0000313|EMBL:QMW36452.1};
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952 {ECO:0000313|EMBL:EED45682.1, ECO:0000313|Proteomes:UP000001875};
RN [1] {ECO:0000313|EMBL:EED45682.1, ECO:0000313|Proteomes:UP000001875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC SRRC 167 {ECO:0000313|Proteomes:UP000001875}, and NRRL3357
RC {ECO:0000313|EMBL:EED45682.1};
RX PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
RN [2] {ECO:0000313|EMBL:QMW36452.1, ECO:0000313|Proteomes:UP000515286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL3357 {ECO:0000313|EMBL:QMW36452.1,
RC ECO:0000313|Proteomes:UP000515286};
RA Fountain J.C., Clevenger J.P., Nadon B., Youngblood R.C., Korani W.,
RA Chang P.-K., Starr D., Wang H., Isett B., Johnston H.R., Wiggins R.,
RA Chu Y., Agarwal G., Kemerait R.C., Pandey M.K., Bhatnagar D.,
RA Ozias-Akins P., Varshney R.K., Scheffler B.E., Vaughn J.N., Guo B.;
RT "Two New Chromosome-Level Aspergillus flavus Reference Genomes Reveal a
RT Large Insertion Potentially Contributing to Isolate Stress Tolerance and
RT Aflatoxin Production.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EQ963485; EED45682.1; -; Genomic_DNA.
DR EMBL; CP059873; QMW36452.1; -; Genomic_DNA.
DR RefSeq; XP_002384618.1; XM_002384577.1.
DR AlphaFoldDB; B8NVY3; -.
DR STRING; 332952.B8NVY3; -.
DR EnsemblFungi; EED45682; EED45682; AFLA_119110.
DR VEuPathDB; FungiDB:AFLA_013905; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_002220_0_0_1; -.
DR OMA; KFVCYGG; -.
DR OrthoDB; 2230730at2759; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR Proteomes; UP000515286; Chromosome 8.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR PANTHER; PTHR43439:SF2; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR43439; PHENYLACETATE-COENZYME A LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
FT DOMAIN 547..630
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1043 AA; 116577 MW; AFDC40F75C0431C7 CRC64;
MGSTNFDQRL MCRVVDELAE SKPEQLFCVQ PISSDLSQGW RNVSMRDLAG AVDYTARWIE
MAMGKGFDFQ PLAYIGANDI RYVVFYLACM KTGYAALLPS TRNSIIATSH VLSATECSKV
VYSAERHKIA EEIGDSVQNV RLYEIPSLWE VFGAPAEPYA FNANFYDLQN KPCIIIHSSG
TTGLPKPVYL TNGFFSVIDN FPRTPTPPGR LNKSITSVAQ GRRLFTMAPM FHLMGLVILS
GAIFHNTPVV LSPERPMTPG LLSQILETAR PEVAMLTPSV IQELSAFQEG LEGLQKFKAI
VFGGAPLSPE VGSKLNEKVA LHSIIGSSEA GFMGALICTH SEDWEYFEWN PYSGIHMESV
DDGVFEAVIR KDEHHEFLCI FHTYPDITEY RTKDLFTPHP TRPGLWKYHG RLDDVIVLSN
GEKFNPTDME NIVESHPLVS KAIIIGQGRF QASLLIQPNW GQWSEDQDKA DFIDRIWPTV
ERANGIAPGH ARVLRTKVAL AKQDTPFALT PKGSVQRRQI YEDYETEINA LYAGEDEECT
DDLPQSTDLE DIKQYIHTVV SQLLSVERIS DTSDIFSLGM DSLQTLQFSK ILQTAVRHLS
ADKNSEPITS QKLYAYPTLD QLSQYVYRLL KGETMEEKAE DEEATRPGRI EGLINKYTND
LSQRAITSFN RSTKNAVILT GSTGSLGNYI LNELLSDREI PMIYCLNRAE DARQKQIASF
KEKGFTIPHD FDERVEFIHA QFGALNLGLS IDKYNELTKS VDLIIHNAWK VNFNHKVEAF
EDPHIRGIRS LVDFSLRSAH SAHIHFISSI STVSAWGPQD GPSVPEIPLD DPDVALRQGY
GESKFVGERI CAIASSIAGV PSSIHRVGQI AGPTTEKGLW NRQEWLPSLV ATSKTLGKLP
NTLGTMPVDW IPIDIMAKIV VDITNSRRAT EDLTRTAAFH LVNPRSSSWE SLIPAIKKHY
KAEVVDMHDW MATLEAFRNP TDGDLQDKPA LKIIDFYKGL ASNHGTFTSV METVKTQAAS
QAMCDLGPID GAIMENWIKQ WQF
//
