ID B8NYN6_ASPFN Unreviewed; 542 AA.
AC B8NYN6;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Choline oxidase (CodA), putative {ECO:0000313|EMBL:EED45322.1};
GN ORFNames=AFLA_012060 {ECO:0000313|EMBL:EED45322.1}, G4B84_011651
GN {ECO:0000313|EMBL:QMW36122.1};
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952 {ECO:0000313|EMBL:EED45322.1, ECO:0000313|Proteomes:UP000001875};
RN [1] {ECO:0000313|EMBL:EED45322.1, ECO:0000313|Proteomes:UP000001875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC SRRC 167 {ECO:0000313|Proteomes:UP000001875}, and NRRL3357
RC {ECO:0000313|EMBL:EED45322.1};
RX PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
RN [2] {ECO:0000313|EMBL:QMW36122.1, ECO:0000313|Proteomes:UP000515286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL3357 {ECO:0000313|EMBL:QMW36122.1,
RC ECO:0000313|Proteomes:UP000515286};
RA Fountain J.C., Clevenger J.P., Nadon B., Youngblood R.C., Korani W.,
RA Chang P.-K., Starr D., Wang H., Isett B., Johnston H.R., Wiggins R.,
RA Chu Y., Agarwal G., Kemerait R.C., Pandey M.K., Bhatnagar D.,
RA Ozias-Akins P., Varshney R.K., Scheffler B.E., Vaughn J.N., Guo B.;
RT "Two New Chromosome-Level Aspergillus flavus Reference Genomes Reveal a
RT Large Insertion Potentially Contributing to Isolate Stress Tolerance and
RT Aflatoxin Production.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; EQ963486; EED45322.1; -; Genomic_DNA.
DR EMBL; CP059873; QMW36122.1; -; Genomic_DNA.
DR RefSeq; XP_002385451.1; XM_002385410.1.
DR AlphaFoldDB; B8NYN6; -.
DR STRING; 332952.B8NYN6; -.
DR EnsemblFungi; EED45322; EED45322; AFLA_012060.
DR VEuPathDB; FungiDB:AFLA_013501; -.
DR eggNOG; KOG1238; Eukaryota.
DR HOGENOM; CLU_002865_7_1_1; -.
DR OMA; NHFESCA; -.
DR OrthoDB; 3714148at2759; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR Proteomes; UP000515286; Chromosome 8.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.30.410.40; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR PANTHER; PTHR11552:SF152; OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2}.
FT DOMAIN 265..279
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 94
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 229
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 542 AA; 60179 MW; 3B5A23A303155769 CRC64;
MATTNDFPAS DVNSYDYIIV GGGTAGCVIA SRLAQYLPNK RVLVIEGGPS DFNDDRVLNL
REWLNLLGGE LDYDYPTTEQ PMGNSHIRHS RAKVLGGCSS HNTLISFRPF EYDCQRWEQQ
GCKGWSFETF TRVLDNLRNT VQPVHARHRN QLCKDWVEAC STAMNIPIIP DFNKEIRQNG
KLTEGVGFFN VSYNPDDGRR SSASVAYIHP ILRGEEKRPN LTILTNAWVS RVNVEGDAVT
GVNLTLQSGV KHTLRAKKET ILCAGAVDTP RLMLLSGLGP QNQLSSLGIE VVKDIPGVGE
NLLDHPESII MWELNRPVPP NQTTMDSDAG IFLRREIPNA AGSDGRSADI MMHCYQIPFD
LNTSRLGYDA PINAFCMTPN IPRPRSRGRI YLTSADPNVK PALDFRYFTD PEGYDAATIV
AGLKAAREIA QQAPFKDWIK REVAPGPKIQ TDEELSEYGR RVAHTVYHPA GTTKMGDVYR
DPLAVVDPQL KVRGLKNVRI ADAGVFPEMP SINPMLTVLA IGERAAELIA EEAGWKREQP
RL
//
