ID B9A070_HUMAN Unreviewed; 195 AA.
AC B9A070;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Hes family bHLH transcription factor 6 {ECO:0000313|Ensembl:ENSP00000387343.1};
GN Name=HES6 {ECO:0000313|Ensembl:ENSP00000387343.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387343.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000387343.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000387343.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AC016757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; B9A070; -.
DR SMR; B9A070; -.
DR MassIVE; B9A070; -.
DR PeptideAtlas; B9A070; -.
DR ProteomicsDB; 7514; -.
DR Antibodypedia; 20277; 340 antibodies from 31 providers.
DR Ensembl; ENST00000409182.1; ENSP00000387343.1; ENSG00000144485.11.
DR UCSC; uc061uei.1; human.
DR HGNC; HGNC:18254; HES6.
DR VEuPathDB; HostDB:ENSG00000144485; -.
DR GeneTree; ENSGT00940000161398; -.
DR ChiTaRS; HES6; human.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000144485; Expressed in ganglionic eminence and 121 other cell types or tissues.
DR ExpressionAtlas; B9A070; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 6.10.250.980; -; 1.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF11; TRANSCRIPTION COFACTOR HES-6; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:B9A070};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 67..100
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 195 AA; 20788 MW; 3B43A9D5AF24316B CRC64;
MAPPAAPGRD RVGREDEDGW ETRGDRKVQA KLENAEVLEL TVRRVQGVLR GRAREREQLQ
AEASERFAAG YIQCMHEVHT FVSTCQAIDA TVAAELLNHL LESMPLREGS SFQDLLGDAL
AGPPRAPGRS GWPAGGAPGS PIPSPPGPGD DLCSDLEEAP EAELSQAPAE GPDLVPAALG
SLTTAQIARS VWRPW
//
