ID B9DS03_STRU0 Unreviewed; 444 AA.
AC B9DS03;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Sodium-dependent malate transporter {ECO:0000313|EMBL:CAR41849.1};
GN Name=malP {ECO:0000313|EMBL:CAR41849.1};
GN OrderedLocusNames=SUB0824 {ECO:0000313|EMBL:CAR41849.1};
OS Streptococcus uberis (strain ATCC BAA-854 / 0140J).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=218495 {ECO:0000313|EMBL:CAR41849.1, ECO:0000313|Proteomes:UP000000449};
RN [1] {ECO:0000313|Proteomes:UP000000449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-854 / 0140J {ECO:0000313|Proteomes:UP000000449};
RX PubMed=19175920; DOI=10.1186/1471-2164-10-54;
RA Ward P.N., Holden M.T.G., Leigh J.A., Lennard N., Bignell A., Barron A.,
RA Clark L., Quail M.A., Woodward J., Barrell B.G., Egan S.A., Field T.R.,
RA Maskell D., Kehoe M., Dowson C.G., Chanter N., Whatmore A.M., Bentley S.D.,
RA Parkhill J.;
RT "Evidence for niche adaptation in the genome of the bovine pathogen
RT Streptococcus uberis.";
RL BMC Genomics 10:54-54(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:citrate (SCF) symporter family.
CC {ECO:0000256|ARBA:ARBA00007546, ECO:0000256|PIRNR:PIRNR005348}.
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DR EMBL; AM946015; CAR41849.1; -; Genomic_DNA.
DR RefSeq; WP_012658332.1; NC_012004.1.
DR AlphaFoldDB; B9DS03; -.
DR STRING; 218495.SUB0824; -.
DR KEGG; sub:SUB0824; -.
DR eggNOG; COG3493; Bacteria.
DR HOGENOM; CLU_041211_0_0_9; -.
DR OrthoDB; 8584824at2; -.
DR Proteomes; UP000000449; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR018025; 2-OHcarbox_trans_Prot/Firm.
DR InterPro; IPR004679; 2-OHcarboxylate_transport.
DR NCBIfam; TIGR00783; ccs; 1.
DR PANTHER; PTHR40033:SF1; CITRATE-SODIUM SYMPORTER; 1.
DR PANTHER; PTHR40033; NA(+)-MALATE SYMPORTER; 1.
DR Pfam; PF03390; 2HCT; 1.
DR PIRSF; PIRSF005348; YxkH; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR005348};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005348};
KW Reference proteome {ECO:0000313|Proteomes:UP000000449};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|PIRNR:PIRNR005348};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005348}.
FT TRANSMEM 29..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 444 AA; 47400 MW; 42D93ADAC2398183 CRC64;
METLQKSVVN PSADLVQAKK NSTFKIGSVP FPVYLTLATL IFITGYLQQL PVNMLGGFAV
ILTMGWLLGT IGANIPVLKN FGGPAILSLL VPSILVFFNL LNPNVLEATN VLMKQANFLY
FYIACLVCGS ILGMNRKILI QGLFRMIIPM LLGMICAMAV GTVVGILLGM EWKHALFYVV
TPVLAGGIGE GILPLSLGYS AITGVSSEQL VAQLIPATII GNFFAIMCTA LLSRFGEKHP
SYSGQGQLVK AGKGEDMSDA LQDNSGQLDI KLMGGGVLTA CSLFIAGGLL QHLTGFPGPV
LMIILAAMLK YMNVIPQETQ NGAKQLYKFI SGNFTFPLMA GLGLLYIPLK DVVATLSWQY
FIVVISVVFT VISVGFFVSR FLNMHPVEAG IISACQSGMG GTGDVAILST ADRMNLMPFA
QVATRLGGAI TVITMTAILR ILFH
//
