ID B9EA98_MACCJ Unreviewed; 245 AA.
AC B9EA98;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=Lactose phosphotransferase system repressor {ECO:0000256|ARBA:ARBA00021390};
GN OrderedLocusNames=MCCL_0452 {ECO:0000313|EMBL:BAH17159.1};
OS Macrococcus caseolyticus (strain JCSC5402).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae; Macrococcus.
OX NCBI_TaxID=458233 {ECO:0000313|EMBL:BAH17159.1, ECO:0000313|Proteomes:UP000001383};
RN [1] {ECO:0000313|EMBL:BAH17159.1, ECO:0000313|Proteomes:UP000001383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCSC5402 {ECO:0000313|EMBL:BAH17159.1,
RC ECO:0000313|Proteomes:UP000001383};
RX PubMed=19074389; DOI=10.1128/JB.01058-08;
RA Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.;
RT "Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402,
RT reflecting the ancestral genome of the human-pathogenic staphylococci.";
RL J. Bacteriol. 191:1180-1190(2009).
CC -!- FUNCTION: Repressor of the lactose catabolism operon. Galactose-6-
CC phosphate is the inducer. {ECO:0000256|ARBA:ARBA00024937}.
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DR EMBL; AP009484; BAH17159.1; -; Genomic_DNA.
DR RefSeq; WP_012656360.1; NC_011999.1.
DR AlphaFoldDB; B9EA98; -.
DR STRING; 458233.MCCL_0452; -.
DR GeneID; 61129752; -.
DR KEGG; mcl:MCCL_0452; -.
DR eggNOG; COG1349; Bacteria.
DR HOGENOM; CLU_060699_1_3_9; -.
DR OrthoDB; 9797223at2; -.
DR Proteomes; UP000001383; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005988; P:lactose metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1360; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR014036; DeoR_C.
DR InterPro; IPR001034; DeoR_HTH.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30363:SF56; DEOR FAMILY REGULATORY PROTEIN-RELATED; 1.
DR PANTHER; PTHR30363; HTH-TYPE TRANSCRIPTIONAL REGULATOR SRLR-RELATED; 1.
DR Pfam; PF00455; DeoRC; 1.
DR Pfam; PF08220; HTH_DeoR; 1.
DR PRINTS; PR00037; HTHLACR.
DR SMART; SM01134; DeoRC; 1.
DR SMART; SM00420; HTH_DEOR; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00894; HTH_DEOR_1; 1.
DR PROSITE; PS51000; HTH_DEOR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Lactose metabolism {ECO:0000256|ARBA:ARBA00022736};
KW Reference proteome {ECO:0000313|Proteomes:UP000001383};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 3..58
FT /note="HTH deoR-type"
FT /evidence="ECO:0000259|PROSITE:PS51000"
SQ SEQUENCE 245 AA; 27877 MW; DAB1164D806C7183 CRC64;
MLTIERHNTI LRLLEIHEII TLQMLIDETH CSESTIRRDL STLEDEGQLI RIHGGAKKVT
EKHRDIALSV KSTKKTKEKE EIAKVAAAQV RNNDCIYLDA GSSTLMMIPY LDQAHITIVT
NGLTHVPPLV EKGYEVYMIG GYIKSDTHAS IGVQAIENLK QFRFDKAFMG ANGVHLTQGI
TTPDIEEAYV KRKAIEKAEQ VYFLVDDSKF DEVTFAKVLD MQEGRTMLIT NRENNLQHRY
SKYLI
//
