ID B9EM59_SALSA Unreviewed; 176 AA.
AC B9EM59;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Neuroblastoma suppressor of tumorigenicity 1 {ECO:0000313|EMBL:ACM08606.1, ECO:0000313|RefSeq:NP_001139908.1};
GN Name=NBL1 {ECO:0000313|EMBL:ACM08606.1};
GN Synonyms=nbl1 {ECO:0000313|RefSeq:NP_001139908.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACM08606.1};
RN [1] {ECO:0000313|EMBL:ACM08606.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Spleen {ECO:0000313|EMBL:ACM08606.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACM08606.1, ECO:0000313|RefSeq:NP_001139908.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Spleen {ECO:0000313|EMBL:ACM08606.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACM08606.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Spleen {ECO:0000313|EMBL:ACM08606.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001139908.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872}.
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DR EMBL; BT056734; ACM08606.1; -; mRNA.
DR RefSeq; NP_001139908.1; NM_001146436.1.
DR STRING; 8030.ENSSSAP00000110492; -.
DR PaxDb; 8030-ENSSSAP00000110492; -.
DR Ensembl; ENSSSAT00000145406; ENSSSAP00000110485; ENSSSAG00000078075.
DR GeneID; 100286497; -.
DR KEGG; sasa:100286497; -.
DR CTD; 4681; -.
DR OrthoDB; 3684148at2759; -.
DR Proteomes; UP000087266; Chromosome ssa12.
DR Bgee; ENSSSAG00000078075; Expressed in liver and 15 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR PANTHER; PTHR15283; GREMLIN 1; 1.
DR PANTHER; PTHR15283:SF5; NEUROBLASTOMA SUPPRESSOR OF TUMORIGENICITY 1; 1.
DR Pfam; PF03045; DAN; 1.
DR SMART; SM00041; CT; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001139908.1}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..176
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001139908.1"
FT /id="PRO_5009732333"
FT DOMAIN 38..125
FT /note="CTCK"
FT /evidence="ECO:0000259|SMART:SM00041"
FT REGION 141..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 176 AA; 19168 MW; C8D64273D80DB525 CRC64;
MWQRIVICCA LLALCSAAPP AHINRLALFP DKSAWCEAKN ITQIVGHTGC QPRSIQNRAC
LGQCFSYSVP NTFPQSTESL VHCDSCMPAQ TQWEVVTLDC PGSDDAPRVD KLVERILHCS
CQSCSKEGAQ EGALMQLYPS ESAQDPPILP ESHHSGTHSQ HAHTHTEPHT HTSDGG
//
