ID B9KE04_CAMLR Unreviewed; 386 AA.
AC B9KE04;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Na(+)/H(+) antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
DE AltName: Full=Sodium/proton antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN Name=nhaA1 {ECO:0000313|EMBL:ACM64792.2};
GN Synonyms=nhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN OrderedLocusNames=Cla_1487 {ECO:0000313|EMBL:ACM64792.2};
OS Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=306263 {ECO:0000313|EMBL:ACM64792.2, ECO:0000313|Proteomes:UP000007727};
RN [1] {ECO:0000313|EMBL:ACM64792.2, ECO:0000313|Proteomes:UP000007727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RM2100 / D67 / ATCC BAA-1060
RC {ECO:0000313|Proteomes:UP000007727};
RX PubMed=18713059; DOI=10.1089/fpd.2008.0101;
RA Miller W.G., Wang G., Binnewies T.T., Parker C.T.;
RT "The complete genome sequence and analysis of the human pathogen
RT Campylobacter lari.";
RL Foodborne Pathog. Dis. 5:371-386(2008).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|HAMAP-Rule:MF_01844}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out);
CC Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01844};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|HAMAP-Rule:MF_01844};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|HAMAP-Rule:MF_01844}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC family. {ECO:0000256|HAMAP-Rule:MF_01844}.
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DR EMBL; CP000932; ACM64792.2; -; Genomic_DNA.
DR RefSeq; WP_012662176.1; NC_012039.1.
DR AlphaFoldDB; B9KE04; -.
DR STRING; 306263.Cla_1488; -.
DR GeneID; 23324513; -.
DR KEGG; cla:CLA_1487; -.
DR PATRIC; fig|306263.5.peg.1468; -.
DR eggNOG; COG0694; Bacteria.
DR eggNOG; COG0822; Bacteria.
DR HOGENOM; CLU_079283_0_0_7; -.
DR Proteomes; UP000007727; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 1.20.1530.10; Na+/H+ antiporter like domain; 1.
DR HAMAP; MF_01844; NhaA; 1.
DR InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR InterPro; IPR004670; NhaA.
DR NCBIfam; TIGR00773; NhaA; 1.
DR PANTHER; PTHR30341:SF0; NA(+)_H(+) ANTIPORTER NHAA; 1.
DR PANTHER; PTHR30341; SODIUM ION/PROTON ANTIPORTER NHAA-RELATED; 1.
DR Pfam; PF06965; Na_H_antiport_1; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|HAMAP-Rule:MF_01844};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519, ECO:0000256|HAMAP-
KW Rule:MF_01844};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01844}; Ion transport {ECO:0000256|HAMAP-Rule:MF_01844};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01844};
KW Reference proteome {ECO:0000313|Proteomes:UP000007727};
KW Sodium {ECO:0000256|HAMAP-Rule:MF_01844};
KW Sodium transport {ECO:0000256|HAMAP-Rule:MF_01844};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01844};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01844}; Transport {ECO:0000256|HAMAP-Rule:MF_01844}.
FT TRANSMEM 58..76
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT TRANSMEM 97..116
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT TRANSMEM 122..143
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT TRANSMEM 180..199
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT TRANSMEM 206..237
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT TRANSMEM 327..349
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
FT TRANSMEM 361..378
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01844"
SQ SEQUENCE 386 AA; 42606 MW; 2E8F22EB3A78341A CRC64;
MQKLQTFVKS ETFPGVLLIF FTVLALILQN SSLTDQYTNF LNIPFGFQAG SLEIFKPLLL
WINDGLIAIF FFAIGLELKY EVTRGQLNSI KAMSLPVFAA LGGMVVPALI FAFFNYKDPF
ALQGWAIPTA TDVAFAVGIL MLLGKRVPTS LKLFLLSLAI FDDLGAIIVI ALFYTSELSV
FAMIAALVCI LALYLLNHFH VTKKSFYIII AIVFWISMLK SGVHATLAGV ITALFIPLQT
KSGESFLKEI EHDLAPWVSY FILPIFAFAN AGVDLKDMDP SFMFSSVSLG IILGLFLGKQ
IGVFLFSYIS IKLGLAKLPQ NVNFKQLYGV CILTGIGFTM SFFIDGLAYQ NSDIFAYSDK
LAILIASLLS AIVGYAYLKL IYSFKK
//
