ID B9KGC4_CAMLR Unreviewed; 675 AA.
AC B9KGC4;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=rep {ECO:0000313|EMBL:ACM64109.1};
GN OrderedLocusNames=Cla_0782 {ECO:0000313|EMBL:ACM64109.1};
OS Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=306263 {ECO:0000313|EMBL:ACM64109.1, ECO:0000313|Proteomes:UP000007727};
RN [1] {ECO:0000313|EMBL:ACM64109.1, ECO:0000313|Proteomes:UP000007727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RM2100 / D67 / ATCC BAA-1060
RC {ECO:0000313|Proteomes:UP000007727};
RX PubMed=18713059; DOI=10.1089/fpd.2008.0101;
RA Miller W.G., Wang G., Binnewies T.T., Parker C.T.;
RT "The complete genome sequence and analysis of the human pathogen
RT Campylobacter lari.";
RL Foodborne Pathog. Dis. 5:371-386(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP000932; ACM64109.1; -; Genomic_DNA.
DR RefSeq; WP_012661492.1; NC_012039.1.
DR AlphaFoldDB; B9KGC4; -.
DR STRING; 306263.Cla_0782; -.
DR GeneID; 7410116; -.
DR KEGG; cla:CLA_0782; -.
DR PATRIC; fig|306263.5.peg.761; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_10_7; -.
DR Proteomes; UP000007727; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000007727}.
FT DOMAIN 4..278
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 279..597
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 675 AA; 77118 MW; FCF3FFE1E1A34460 CRC64;
MPLSRLNEEQ YKAACAPFGH NLIIASAGTG KTSTIVARIA FLLQNGTNPE KIMLLTFTNK
ASKEMIERLG RYFDKNITSK ITAGTFHSTA YTLLKQLNHE IILKQASELK VLLRSIFEKR
TFHHLSDVKP YMASYLYDVY SLFQNTNSNL DNFYEWFCQN YDEQAVYAEI YEDILKEYEE
EKARFNYVDF NDLLIKLKYA LKEHHFEFDE ILVDEYQDTN TLQGSLIDAF KSKSLFCVGD
YDQSIYAFNG ADISIIGSFK DRFLDAKIFT LNKNYRSSKN ILALANKVIL NNERLYPKEL
IVTREGDFKA PSLLTFNELF DQYSTIAKII LQSGVDLNEI AVIFRNNSSA DGIEVALREL
GISSKRKGSG SFFESLEVKA FCSMLAIILN PKDIMAFIHL LEYTKGVGGV LAKDIFDSLL
KLGHANLIKG FLEPDTSINL KKYKKQSYQL GLFDDIEELA SPLRFNLESE FNTHPILSLP
KINETCAKNL EKLCLFIKKA SECKISTQLV NLILENDYFK EICDILATKR ATNKNSNVDL
NKKNEILEKI SAKMFVLKEL AKNYSDNYKY YNFLTLGASE MSNGNGVNLL SIHASKGLEF
ELVFVIDLAQ GRFPNQKLMS MGGSLEEERR LFYVAVTRAK DTLYLSYAKY DKIKKSNYQP
SCFLIEAGMC KEEQK
//
