ID B9KJ22_ANAMF Unreviewed; 291 AA.
AC B9KJ22;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Geranyltranstransferase (Farnesyl-diphosphate synthase)(IspA) {ECO:0000313|EMBL:ACM49484.1};
DE EC=2.5.1.10 {ECO:0000313|EMBL:ACM49484.1};
GN Name=ispA {ECO:0000313|EMBL:ACM49484.1};
GN OrderedLocusNames=AMF_645 {ECO:0000313|EMBL:ACM49484.1};
OS Anaplasma marginale (strain Florida).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Anaplasma.
OX NCBI_TaxID=320483 {ECO:0000313|EMBL:ACM49484.1, ECO:0000313|Proteomes:UP000007307};
RN [1] {ECO:0000313|EMBL:ACM49484.1, ECO:0000313|Proteomes:UP000007307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Florida {ECO:0000313|EMBL:ACM49484.1,
RC ECO:0000313|Proteomes:UP000007307};
RX PubMed=19134224; DOI=10.1186/1471-2164-10-16;
RA Dark M.J., Herndon D.R., Kappmeyer L.S., Gonzales M.P., Nordeen E.,
RA Palmer G.H., Knowles D.P. Jr., Brayton K.A.;
RT "Conservation in the face of diversity: multistrain analysis of an
RT intracellular bacterium.";
RL BMC Genomics 10:16-16(2009).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|RuleBase:RU004466}.
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DR EMBL; CP001079; ACM49484.1; -; Genomic_DNA.
DR AlphaFoldDB; B9KJ22; -.
DR STRING; 320483.AMF_645; -.
DR KEGG; amf:AMF_645; -.
DR eggNOG; COG0142; Bacteria.
DR HOGENOM; CLU_014015_0_1_5; -.
DR Proteomes; UP000007307; Chromosome.
DR GO; GO:0004337; F:geranyltranstransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00685; Trans_IPPS_HT; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR43281; FARNESYL DIPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR43281:SF1; FARNESYL DIPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SFLD; SFLDG01017; Polyprenyl_Transferase_Like; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
PE 3: Inferred from homology;
KW Isoprene biosynthesis {ECO:0000256|ARBA:ARBA00023229};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000007307};
KW Transferase {ECO:0000256|RuleBase:RU004466, ECO:0000313|EMBL:ACM49484.1}.
SQ SEQUENCE 291 AA; 31320 MW; C2B73FCD720A3532 CRC64;
MITPPMHHSY SDIQQKVEDF ASLVQKELAQ VVHEKAECPS AALHEALGYV ISNPGKCIRS
FLASTSAQVF GVSTERTLRL SAAIEVVHAY SLVHDDLPSM DNSPIRRGKE SCHIKFGEAV
AVLTGNALLT LTFELLSTMN EGCAVRCEII ELLSKACGRC GMIAGQMLDM EAHSSTSFEG
VRRIHELKTA RLFSAACEAG AVLGGASAEE RAALAKYGAA LGCAFQAKDD LSDAWEDGER
CYGSMAHILG MDETQGYVDG LLRKCEEHLR KLPGNVDTLG GLVVFVENLS V
//
