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Database: UniProt
Entry: B9KQC8
LinkDB: B9KQC8
Original site: B9KQC8 
ID   ALR_RHOSK               Reviewed;         349 AA.
AC   B9KQC8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   05-DEC-2018, entry version 56.
DE   RecName: Full=Alanine racemase {ECO:0000255|HAMAP-Rule:MF_01201};
DE            EC=5.1.1.1 {ECO:0000255|HAMAP-Rule:MF_01201};
GN   Name=alr; OrderedLocusNames=RSKD131_0775;
OS   Rhodobacter sphaeroides (strain KD131 / KCTC 12085).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Rhodobacter.
OX   NCBI_TaxID=557760;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KD131 / KCTC 12085;
RX   PubMed=19028901; DOI=10.1128/JB.01565-08;
RA   Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S.,
RA   Lee J.K.;
RT   "Complete genome sequence of Rhodobacter sphaeroides KD131.";
RL   J. Bacteriol. 191:1118-1119(2009).
CC   -!- FUNCTION: Catalyzes the interconversion of L-alanine and D-
CC       alanine. May also act on other amino acids. {ECO:0000255|HAMAP-
CC       Rule:MF_01201}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-alanine = D-alanine; Xref=Rhea:RHEA:20249,
CC         ChEBI:CHEBI:57416, ChEBI:CHEBI:57972; EC=5.1.1.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01201};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01201};
CC   -!- PATHWAY: Amino-acid biosynthesis; D-alanine biosynthesis; D-
CC       alanine from L-alanine: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_01201}.
CC   -!- SIMILARITY: Belongs to the alanine racemase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01201}.
DR   EMBL; CP001150; ACM00635.1; -; Genomic_DNA.
DR   RefSeq; WP_009564494.1; NC_011963.1.
DR   ProteinModelPortal; B9KQC8; -.
DR   SMR; B9KQC8; -.
DR   EnsemblBacteria; ACM00635; ACM00635; RSKD131_0775.
DR   KEGG; rsk:RSKD131_0775; -.
DR   HOGENOM; HOG000031445; -.
DR   KO; K01775; -.
DR   OMA; SGAAMYH; -.
DR   UniPathway; UPA00042; UER00497.
DR   Proteomes; UP000001597; Chromosome 1.
DR   GO; GO:0008784; F:alanine racemase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030632; P:D-alanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.40.37.10; -; 1.
DR   Gene3D; 3.20.20.10; -; 1.
DR   HAMAP; MF_01201; Ala_racemase; 1.
DR   InterPro; IPR000821; Ala_racemase.
DR   InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR   InterPro; IPR011079; Ala_racemase_C.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   Pfam; PF00842; Ala_racemase_C; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PRINTS; PR00992; ALARACEMASE.
DR   SMART; SM01005; Ala_racemase_C; 1.
DR   SUPFAM; SSF50621; SSF50621; 1.
DR   SUPFAM; SSF51419; SSF51419; 1.
DR   TIGRFAMs; TIGR00492; alr; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; Pyridoxal phosphate.
FT   CHAIN         1    349       Alanine racemase.
FT                                /FTId=PRO_1000164607.
FT   ACT_SITE     35     35       Proton acceptor; specific for D-alanine.
FT                                {ECO:0000255|HAMAP-Rule:MF_01201}.
FT   ACT_SITE    244    244       Proton acceptor; specific for L-alanine.
FT                                {ECO:0000255|HAMAP-Rule:MF_01201}.
FT   BINDING     130    130       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_01201}.
FT   BINDING     292    292       Substrate; via amide nitrogen.
FT                                {ECO:0000255|HAMAP-Rule:MF_01201}.
FT   MOD_RES      35     35       N6-(pyridoxal phosphate)lysine.
FT                                {ECO:0000255|HAMAP-Rule:MF_01201}.
SQ   SEQUENCE   349 AA;  37052 MW;  1C8D83E8C5A21DB9 CRC64;
     MATATLTIDL DAIAANWRAL DQMTASDCQT GAVVKADSYG LGAAKVAHAL ARAGARRFFV
     ATCEEGADVR RALGSGPQIC VFSGHMEGDT ALIRDFDLTP MLNSIDQLTR HFEALGGQPF
     GLQLDSGMNR LGLEPGEWEA VAGFALEAGP ELLMSHLACS DDPDHPMNAE QLGAFRAMTD
     GTGVPRSLSA TGGILLGPAW HFELTRPGIG LYGGRPFEEA RPVVRLSLPV IQVREVEIGE
     PVGYSNTWTA EHTSTIATVA AGYADGLPRT LSSRATLYAG RVPCPLVGRV SMDLITVDVS
     HLPEVPETLD ILGPHQTPDD LADTAGTIGY EILTSLGRRY QRRYGALAA
//
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