ID B9L565_THERP Unreviewed; 516 AA.
AC B9L565;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=4-hydroxyphenylacetate 3-monooxygenase oxygenase component (4-HPA 3-monooxygenase large component) (4-HPA 3-hydroxylase) {ECO:0000313|EMBL:ACM06547.1};
DE EC=1.14.14.- {ECO:0000313|EMBL:ACM06547.1};
GN OrderedLocusNames=trd_A0929 {ECO:0000313|EMBL:ACM06547.1};
OS Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2).
OG Plasmid Tros {ECO:0000313|Proteomes:UP000000447}.
OC Bacteria; Thermomicrobiota; Thermomicrobia; Thermomicrobiales;
OC Thermomicrobiaceae; Thermomicrobium.
OX NCBI_TaxID=309801 {ECO:0000313|EMBL:ACM06547.1, ECO:0000313|Proteomes:UP000000447};
RN [1] {ECO:0000313|EMBL:ACM06547.1, ECO:0000313|Proteomes:UP000000447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27502 / DSM 5159 / P-2
RC {ECO:0000313|Proteomes:UP000000447};
RC PLASMID=Tros {ECO:0000313|Proteomes:UP000000447};
RX PubMed=19148287; DOI=10.1371/journal.pone.0004207;
RA Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A.,
RA Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L.,
RA Eisen J.A.;
RT "Complete genome sequence of the aerobic CO-oxidizing thermophile
RT Thermomicrobium roseum.";
RL PLoS ONE 4:E4207-E4207(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001276; ACM06547.1; -; Genomic_DNA.
DR RefSeq; WP_012642534.1; NC_011961.1.
DR AlphaFoldDB; B9L565; -.
DR KEGG; tro:trd_A0929; -.
DR eggNOG; COG2368; Bacteria.
DR HOGENOM; CLU_023920_2_1_0; -.
DR OrthoDB; 9785230at2; -.
DR Proteomes; UP000000447; Plasmid Tros.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR Gene3D; 1.10.3140.10; 4-hydroxybutyryl-coa dehydratase, domain 1; 1.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 1.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR InterPro; IPR024677; HpaB/PvcC.
DR InterPro; IPR004925; HpaB/PvcC/4-BUDH.
DR InterPro; IPR024719; HpaB/PvcC/4-BUDH_C.
DR InterPro; IPR024674; HpaB/PvcC/4-BUDH_N.
DR PANTHER; PTHR36117; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR PANTHER; PTHR36117:SF3; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR Pfam; PF03241; HpaB; 1.
DR Pfam; PF11794; HpaB_N; 1.
DR PIRSF; PIRSF500125; 4_HPA_large; 1.
DR PIRSF; PIRSF000331; HpaA_HpaB; 1.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000331-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Monooxygenase {ECO:0000313|EMBL:ACM06547.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ACM06547.1}; Plasmid {ECO:0000313|EMBL:ACM06547.1}.
FT DOMAIN 6..270
FT /note="HpaB/PvcC/4-BUDH N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11794"
FT DOMAIN 277..478
FT /note="HpaB/PvcC/4-BUDH C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03241"
FT BINDING 145..147
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
FT BINDING 186
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
SQ SEQUENCE 516 AA; 58340 MW; E23FE91A59545435 CRC64;
MTQPLTGTEY LESLRDGREV WIYGERVRDV TTHPAFRNAA RMLARLYDAL HDSARQEDLL
APLDGEGGRT HAFFRVFHEP ADLERALEAV AAWQRLTWGW MGRTPDYKAS LAATLGAWPE
YFEPYAENAR RWYRAIAQRV LFLNHAIVNP PVDRHRPVHE AADVVLHVVE ETERGIVVSG
AKVVATGSAL THYNFIAHYG PMPVQDERFA FAALVPMNVP GLKLICRPSY EMTAAVMGSP
FDYPLSSRFD ENDAILVFDR VEIPWENVFI YRDLQKANTF VPATGFLNRA LFHGCVRLAV
KLDFLVGAFL EATHVVGTDA FRGVQVNLGE VIAWRHLFWS LAWAMVKRPD PGPNGTLLPN
LEAGQAYRVL MTVAYPRIRD LIERTLASAL IYANSNAVDF LVPELRPYLD RYLRGSHGTD
AIGKMKIMKL LWDAIGSEFG SRHELYERNF AGNYENVRLE TLLLAQLSGL TQSLQNFVRA
CMDEYDITGW KAADLIDPTD VNVPRQHLQQ RAAESV
//