ID B9L6V5_NAUPA Unreviewed; 293 AA.
AC B9L6V5;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=lipopolysaccharide heptosyltransferase II {ECO:0000256|ARBA:ARBA00044042};
DE EC=2.4.99.24 {ECO:0000256|ARBA:ARBA00044042};
GN Name=rfaF {ECO:0000313|EMBL:ACM92163.1};
GN OrderedLocusNames=NAMH_1713 {ECO:0000313|EMBL:ACM92163.1};
OS Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Nautiliales;
OC Nautiliaceae; Nautilia.
OX NCBI_TaxID=598659 {ECO:0000313|EMBL:ACM92163.1, ECO:0000313|Proteomes:UP000000448};
RN [1] {ECO:0000313|EMBL:ACM92163.1, ECO:0000313|Proteomes:UP000000448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1463 / DSM 18972 / AmH
RC {ECO:0000313|Proteomes:UP000000448};
RX PubMed=19197347; DOI=10.1371/journal.pgen.1000362;
RA Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K.,
RA Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C.;
RT "Adaptations to submarine hydrothermal environments exemplified by the
RT genome of Nautilia profundicola.";
RL PLoS Genet. 5:E1000362-E1000362(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-
CC [alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-
CC (1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid
CC A + H(+); Xref=Rhea:RHEA:74071, ChEBI:CHEBI:15378, ChEBI:CHEBI:61506,
CC ChEBI:CHEBI:193068, ChEBI:CHEBI:193069, ChEBI:CHEBI:456216;
CC EC=2.4.99.24; Evidence={ECO:0000256|ARBA:ARBA00043830};
CC -!- SIMILARITY: Belongs to the glycosyltransferase 9 family.
CC {ECO:0000256|ARBA:ARBA00043995}.
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DR EMBL; CP001279; ACM92163.1; -; Genomic_DNA.
DR RefSeq; WP_012663535.1; NC_012115.1.
DR AlphaFoldDB; B9L6V5; -.
DR STRING; 598659.NAMH_1713; -.
DR CAZy; GT9; Glycosyltransferase Family 9.
DR KEGG; nam:NAMH_1713; -.
DR eggNOG; COG0859; Bacteria.
DR HOGENOM; CLU_038371_7_0_7; -.
DR OrthoDB; 9797795at2; -.
DR Proteomes; UP000000448; Chromosome.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002201; Glyco_trans_9.
DR InterPro; IPR011910; RfaF.
DR NCBIfam; TIGR02195; heptsyl_trn_II; 1.
DR PANTHER; PTHR30160:SF7; ADP-HEPTOSE--LPS HEPTOSYLTRANSFERASE 2; 1.
DR PANTHER; PTHR30160; TETRAACYLDISACCHARIDE 4'-KINASE-RELATED; 1.
DR Pfam; PF01075; Glyco_transf_9; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACM92163.1}.
SQ SEQUENCE 293 AA; 33163 MW; AB9BDD89136C5569 CRC64;
MKLLIEPPTW LGDAVMASGA IKALLDELRP EKRIVFGSFV ATELLKEWFD EVIVIDKKHK
FKQFMDFPKA DIFISFRTSL YSKILGLKVK KSFYFDKNLS GHMVEKYSKY VNTIIGKNEV
YSPVLPFEPK YFQKPTLGIN PGATYGSAKR WYPEEFAKVA NALGEKYDVI IFGGPGEEDI
AKDIEKNLEI SNYRNLCGKL SIKELCEHIG GLDLFITNDS GPMHIAAAYN VPIVAVFGPT
NYKETSPWSS NYKIVTKDLE CAPCMKRECP LGHHKCMKEI KAEDVLKAVK ELV
//
