ID B9LNX9_HALLT Unreviewed; 733 AA.
AC B9LNX9;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Archaeal Rqc2 homolog aRqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=aRqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN OrderedLocusNames=Hlac_1479 {ECO:0000313|EMBL:ACM57067.1};
OS Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM
OS 34).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Halorubraceae; Halorubrum.
OX NCBI_TaxID=416348 {ECO:0000313|EMBL:ACM57067.1, ECO:0000313|Proteomes:UP000000740};
RN [1] {ECO:0000313|EMBL:ACM57067.1, ECO:0000313|Proteomes:UP000000740}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34
RC {ECO:0000313|Proteomes:UP000000740};
RX PubMed=27617060; DOI=10.1186/s40793-016-0194-2;
RA Anderson I.J., DasSarma P., Lucas S., Copeland A., Lapidus A.,
RA Del Rio T.G., Tice H., Dalin E., Bruce D.C., Goodwin L., Pitluck S.,
RA Sims D., Brettin T.S., Detter J.C., Han C.S., Larimer F., Hauser L.,
RA Land M., Ivanova N., Richardson P., Cavicchioli R., DasSarma S.,
RA Woese C.R., Kyrpides N.C.;
RT "Complete genome sequence of the Antarctic Halorubrum lacusprofundi type
RT strain ACAM 34.";
RL Stand. Genomic Sci. 11:70-70(2016).
CC -!- FUNCTION: Probably part of the ribosome quality control system (RQC).
CC May mediate the addition of alanine residues (Ala tailing) to
CC incompletely synthesized nascent chains from stalled ribosomes, leading
CC to their degradation. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
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DR EMBL; CP001365; ACM57067.1; -; Genomic_DNA.
DR RefSeq; WP_015910209.1; NC_012029.1.
DR AlphaFoldDB; B9LNX9; -.
DR GeneID; 7400307; -.
DR KEGG; hla:Hlac_1479; -.
DR eggNOG; arCOG01695; Archaea.
DR HOGENOM; CLU_003612_2_1_2; -.
DR Proteomes; UP000000740; Chromosome 1.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_A; RqcH_A; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR010979; Ribosomal_uS13-like_H2TH.
DR InterPro; IPR043681; RqcH_archaeal.
DR NCBIfam; NF041120; RqcH_arch; 1.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
DR SUPFAM; SSF46946; S13-like H2TH domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00844};
KW Reference proteome {ECO:0000313|Proteomes:UP000000740};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_00844};
KW tRNA-binding {ECO:0000256|HAMAP-Rule:MF_00844}.
FT DOMAIN 525..641
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT REGION 300..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 328..355
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
FT COMPBIAS 471..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..503
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 81225 MW; 4838E133C70B716E CRC64;
MDQKRELSSI DLAALVTELN RYEGAKVDKA YLYDDDLLRL KLRDFDRGRV ELMIEVGDIK
RAHVADPENV ADAPGRPPNF AKMLRNRMSG ADFAGVEQYE FDRILTFEFE REDENTTLVA
ELFGQGNVAA LDETGEVVGS LQTVRLKSRT VAPGAQYEYP ASRLNPLDVS LGGFKRHMRE
SDSDVVRTLA TQLNLGGLYA EEVCTRAGVE KETPIDDVTD DQLRALHEAL ERIGERLRSG
DVDPRVYEEE LSDDEAEDRD PRVVDVTPFP LSEHEGLPSV GFDSFNAAVD EYFYRLDRDG
SEEGEAPADA SPSRPDFEEE IGKQERIVEQ QQGAIEGFEE QAEAERERAE LLYAEYDLVD
EVLSTVQEAR EAEVPWDEIA ETLDAGAEQG IPAAETVVDV DGGEGTVTVE LRGGDGEDDD
GETTRIELDA SAGVEVNADR LYQEAKRIEG KKEGAMEAIK STRAELEAVK ERKAEWEAKE
AAADETAGDG ADDGEEEEDG EEYQTDWLSR SSIPIRSPDD WYDRFRWFYT STGYLVIGGR
NADQNEELVK KYMGKHDRFF HTQAHGGPVT LLKAAGPSES ADPVDFSEET LREVAQFAVS
YSSDWKDGRG AGDAYMVEPD QVSKTPESGE YIEKGSFVIR GDRTYFEDVP CRIAVGVQCE
PVTQAIGGPP SAIVDRVATS VTLEPGMYAQ NDAAMMVYRE LKGRFADQSF VRKVASADQL
QEFIPAGGSD IVD
//
