ID   B9LSH2_HALLT            Unreviewed;      1227 AA.
AC   B9LSH2;
DT   24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   24-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   OrderedLocusNames=Hlac_2343 {ECO:0000313|EMBL:ACM57919.1};
OS   Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM
OS   34).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Halorubraceae; Halorubrum.
OX   NCBI_TaxID=416348 {ECO:0000313|EMBL:ACM57919.1, ECO:0000313|Proteomes:UP000000740};
RN   [1] {ECO:0000313|EMBL:ACM57919.1, ECO:0000313|Proteomes:UP000000740}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34
RC   {ECO:0000313|Proteomes:UP000000740};
RX   PubMed=27617060; DOI=10.1186/s40793-016-0194-2;
RA   Anderson I.J., DasSarma P., Lucas S., Copeland A., Lapidus A.,
RA   Del Rio T.G., Tice H., Dalin E., Bruce D.C., Goodwin L., Pitluck S.,
RA   Sims D., Brettin T.S., Detter J.C., Han C.S., Larimer F., Hauser L.,
RA   Land M., Ivanova N., Richardson P., Cavicchioli R., DasSarma S.,
RA   Woese C.R., Kyrpides N.C.;
RT   "Complete genome sequence of the Antarctic Halorubrum lacusprofundi type
RT   strain ACAM 34.";
RL   Stand. Genomic Sci. 11:70-70(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CP001365; ACM57919.1; -; Genomic_DNA.
DR   AlphaFoldDB; B9LSH2; -.
DR   KEGG; hla:Hlac_2343; -.
DR   eggNOG; arCOG00802; Archaea.
DR   HOGENOM; CLU_273708_0_0_2; -.
DR   Proteomes; UP000000740; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000000740}.
FT   DOMAIN          26..444
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          457..753
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          834..868
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          963..987
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         47..54
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1227 AA;  134770 MW;  D77BA9ECC95AE52B CRC64;
     MESRRETVSD DGGDGDGDAD PIRLRGAQRE IRDAYFASDS GLFTLDCVPG AGKSVVAHHV
     AAEDILRRYA AGDPTPEQHV TVVSFNRDEA ADIVPAICDR LQAIVEHDLV PTAADISGAE
     LRYLRQRVRQ APYAGTIDGL LREIFREFAR DIGFDEMPSV GNDALLKRVH RDCYESLRND
     PEHARRLRDL EAAYPDGEYD EGVDEMLADA LTYCRDRRLS TEAFRSELEQ TRDSAYPGGK
     PDSFDDIVRS VERFANGDEN ASEGTGERVR ETVIGPDRER LLDADRELYD AWDARIDDFC
     TVLSAYRTRY RAAVREYGAV SHTDVASLVD AYFDRSGERS DLPEPLRSVD GSHRDRVLRT
     YRSRIRSLVI DEAQDVSAVQ HAALSHVVTS ESRVFACGDG LQGIYLWRHA DPRWFAAATT
     EGTYLGVDWD THENRTATTT YRCVPDIAAG INAIAEPVFS DPARGNLGDL DASYPRLDAA
     RDGGEGGDGA AVHVSSFAGI GHPGSAMWAD PDGELGEANM LATHISRGLA DGTFCNDDGD
     PLGVTVLFRR GTRMPEYEAA FAAEGLRVRT ATDALFDCPA VETALAACEW LTAPGSPQRT
     SKLLTESPLN AAFDAAPFES RSWDLDRVLD DDPAAVGEEQ RGILRGLVRL RDRSDAFGRL
     PASEYVEDVI EALALRADPN GCVGDTDPDQ RVANLDALVE TLSEWEGDNS YSPSELVDLA
     EPFREDPGVG PTQPSAAGAA YDVEFRTIHR AKGDQDDVVV VADPGFDIWS HGPHARWFVA
     QGPLAGLAPP TNTEVPDDIA IPPFDGGLYG VGDDWDRDAG LRWATARWRD TVSTSVSDSA
     SDSAKDSGSD SAKDSGSDSA NDSADRDALV GPDRLRRVAG NERAEAWRLL YVALTRARDH
     LVVPLPRSNL EEDRTRDRWL DAIRDGLAFR RGGTDSYELL LDSDPNRDAI EIGVNDADLF
     ARRARPAPRT GRDEATESPP RRDRLDPWVP RFLSPSTMYP LTEDVDRYAL AHLLGEPLHT
     TTNEVSGDLP LRFDRLGPEA VGTCLHDALT ELVARGVDER AIRTTGPEVR TAFDEAVNAI
     PEPVGEAERE GMFAFFETVL DDFLDSDLWD RIADPATVVD TERPLDGLAE VGDLGVEIHG
     RADFVVEYPT GDRFVTDVKI ALTEPSSETR RRYELQIAAY AFLARQSGAS DVRVHRTVET
     FGVATETTAT SWPPDIVHRR LQRFLGR
//