ID B9LV19_HALLT Unreviewed; 320 AA.
AC B9LV19;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Archaeosortase A {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=Hlac_0898 {ECO:0000313|EMBL:ACM56496.1};
OS Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM
OS 34).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Halorubraceae; Halorubrum.
OX NCBI_TaxID=416348 {ECO:0000313|EMBL:ACM56496.1, ECO:0000313|Proteomes:UP000000740};
RN [1] {ECO:0000313|EMBL:ACM56496.1, ECO:0000313|Proteomes:UP000000740}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34
RC {ECO:0000313|Proteomes:UP000000740};
RX PubMed=27617060; DOI=10.1186/s40793-016-0194-2;
RA Anderson I.J., DasSarma P., Lucas S., Copeland A., Lapidus A.,
RA Del Rio T.G., Tice H., Dalin E., Bruce D.C., Goodwin L., Pitluck S.,
RA Sims D., Brettin T.S., Detter J.C., Han C.S., Larimer F., Hauser L.,
RA Land M., Ivanova N., Richardson P., Cavicchioli R., DasSarma S.,
RA Woese C.R., Kyrpides N.C.;
RT "Complete genome sequence of the Antarctic Halorubrum lacusprofundi type
RT strain ACAM 34.";
RL Stand. Genomic Sci. 11:70-70(2016).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001365; ACM56496.1; -; Genomic_DNA.
DR RefSeq; WP_015909647.1; NC_012029.1.
DR AlphaFoldDB; B9LV19; -.
DR GeneID; 7401269; -.
DR KEGG; hla:Hlac_0898; -.
DR eggNOG; arCOG04471; Archaea.
DR HOGENOM; CLU_065734_1_0_2; -.
DR Proteomes; UP000000740; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR014522; ArtA.
DR InterPro; IPR026392; Exo/Archaeosortase_dom.
DR NCBIfam; TIGR04178; exo_archaeo; 1.
DR NCBIfam; TIGR04125; exosort_PGF_TRM; 1.
DR PIRSF; PIRSF025737; Cyco1; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000000740};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 184
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR025737-1"
FT ACT_SITE 225
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR025737-1"
FT SITE 264
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000256|PIRSR:PIRSR025737-2"
SQ SEQUENCE 320 AA; 35149 MW; 5FFEFEBBFB28C3F2 CRC64;
MFGSGVPAVL TLLPDTFTFA WLVAILFAVA WLLDSRGLAA GRSLAAGTWA LFGLFWLTTV
PYFAFEHQSY VESILALVGV PACIYAGYLL YNGRGSLFTL TRAIAIMLFI YLPFETIPAF
TLGGMAFPEP RRILIEAVAT QTGMLIDLLG YVPERVASSE GYNAAYLWTL DDGHTYRIDI
VLACTGLGSM AIFGGLVAAV EAPLRRKLRG LAVSVSLIYV LNILRTTFIS VVAGNQYMQW
YPDLVLAMFG ASDPYRVSFL ISDRIMSQLL AVVALIGITF LVVRELPELV VILEDVLYLL
TGEEHDLTEA LELPREPTNR
//
