ID B9LZB2_GEODF Unreviewed; 554 AA.
AC B9LZB2;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobamide-binding-like domain and TPR domain {ECO:0000313|EMBL:ACM20665.1};
GN OrderedLocusNames=Geob_2311 {ECO:0000313|EMBL:ACM20665.1};
OS Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32) (Geobacter
OS daltonii).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geotalea.
OX NCBI_TaxID=316067 {ECO:0000313|EMBL:ACM20665.1, ECO:0000313|Proteomes:UP000007721};
RN [1] {ECO:0000313|EMBL:ACM20665.1, ECO:0000313|Proteomes:UP000007721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22248 / JCM 15807 / FRC-32
RC {ECO:0000313|Proteomes:UP000007721};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA Kostka J., Richardson P.;
RT "Complete sequence of Geobacter sp. FRC-32.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP001390; ACM20665.1; -; Genomic_DNA.
DR RefSeq; WP_012647394.1; NC_011979.1.
DR AlphaFoldDB; B9LZB2; -.
DR STRING; 316067.Geob_2311; -.
DR KEGG; geo:Geob_2311; -.
DR eggNOG; COG1032; Bacteria.
DR eggNOG; COG4783; Bacteria.
DR HOGENOM; CLU_483774_0_0_7; -.
DR OrthoDB; 9762608at2; -.
DR Proteomes; UP000007721; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF17; MG-PROTOPORPHYRIN IX MONOMETHYL ESTER OXIDATIVE CYCLASE 66KD SUBUNIT; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000007721};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 9..141
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 184..402
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REPEAT 477..510
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 511..544
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 554 AA; 61788 MW; 2857DF8090C14312 CRC64;
MTQVLLAYKS NSAGANDPYT SLLPVGLGYI NAVLNSHGYA SQMANFSKFS WKETESIISR
MRPQVLGIAQ FTHNRFESVK LAALAKKINP ATFVVFGGPH ATHQYREILD RHKQVDAVVL
GEGEESFLEL VATLKDETPR LAEIKGIAFR TANGIISTTA RPPIADLDSV PFPAAYMDNA
LGVDLHRQLE FIITSRGCPA ACLFCSSPLF WGKSLRLRSP RNMVDEITLI RNRCGLIYFS
IRDDTFTADK GRVMEFCRLL RKEKVFILWN CQSRVSAVDE ELLFAMKRAG CECIQFGVES
GSPRILKALG KGINTEQVRK ASALVRKAGM NLSIYLITGV KNEVDADTDA TIKLVEAIQA
HDGQVSPLAY YPGTGIFSKD VKAGVIGREI FNEDRHEALY VRDDAFVGSS TQRLLETVAK
VGKGAGYGER DFQSHKKLLG YCHATNIMSG EMYEDEGRWQ LAEREYREIA EREPENPWGW
LLLGALYGRL GALEKACSKY KRVLTVVPAH APAFSDLGEL MMLMGKTWEG MEYFKRALEL
NPYDPRAKQA LKTR
//
