ID B9M8X5_GEODF Unreviewed; 346 AA.
AC B9M8X5;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Lipopolysaccharide heptosyltransferase 1 {ECO:0000256|ARBA:ARBA00044190};
DE EC=2.4.99.23 {ECO:0000256|ARBA:ARBA00044041};
DE AltName: Full=ADP-heptose:lipopolysaccharide heptosyltransferase I {ECO:0000256|ARBA:ARBA00044330};
GN OrderedLocusNames=Geob_2116 {ECO:0000313|EMBL:ACM20471.1};
OS Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32) (Geobacter
OS daltonii).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geotalea.
OX NCBI_TaxID=316067 {ECO:0000313|EMBL:ACM20471.1, ECO:0000313|Proteomes:UP000007721};
RN [1] {ECO:0000313|EMBL:ACM20471.1, ECO:0000313|Proteomes:UP000007721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22248 / JCM 15807 / FRC-32
RC {ECO:0000313|Proteomes:UP000007721};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA Kostka J., Richardson P.;
RT "Complete sequence of Geobacter sp. FRC-32.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-
CC alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-
CC (2->4)]-alpha-Kdo-(2->6)-lipid A + H(+); Xref=Rhea:RHEA:74067,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:61506, ChEBI:CHEBI:176431,
CC ChEBI:CHEBI:193068, ChEBI:CHEBI:456216; EC=2.4.99.23;
CC Evidence={ECO:0000256|ARBA:ARBA00043802};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004713}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004515}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004515}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004515}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 9 family.
CC {ECO:0000256|ARBA:ARBA00043995}.
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DR EMBL; CP001390; ACM20471.1; -; Genomic_DNA.
DR AlphaFoldDB; B9M8X5; -.
DR STRING; 316067.Geob_2116; -.
DR CAZy; GT9; Glycosyltransferase Family 9.
DR KEGG; geo:Geob_2116; -.
DR eggNOG; COG0859; Bacteria.
DR HOGENOM; CLU_038371_6_0_7; -.
DR OrthoDB; 9760688at2; -.
DR Proteomes; UP000007721; Chromosome.
DR GO; GO:0008920; F:lipopolysaccharide heptosyltransferase activity; IEA:InterPro.
DR GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:InterPro.
DR CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002201; Glyco_trans_9.
DR InterPro; IPR011908; LipoPS_heptosylTferase-I.
DR NCBIfam; TIGR02193; heptsyl_trn_I; 1.
DR PANTHER; PTHR30160:SF19; LIPOPOLYSACCHARIDE HEPTOSYLTRANSFERASE 1; 1.
DR PANTHER; PTHR30160; TETRAACYLDISACCHARIDE 4'-KINASE-RELATED; 1.
DR Pfam; PF01075; Glyco_transf_9; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Lipopolysaccharide biosynthesis {ECO:0000256|ARBA:ARBA00022985};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007721};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACM20471.1}.
SQ SEQUENCE 346 AA; 38824 MW; F8BA37A6738A4B3D CRC64;
MRVLIVKMSA MGDIIHALPV LDYLHNVSPG IEIDWLVEEP FLDVVAGNPQ ISMIHTARSK
AWRKSLFSSR TFSETAALKR TLQERDYDIV FDIQGNIKSG VYGWLTGADN RIGFDAEVLQ
ERLNMLFTTR RIPLRPQDSH ITEQYLRLVS VPFGRDYREM QLVSDIYTTP EDDAAAEALL
STLADGLVFL FHYGTTWQTK FWREESWVAL GRDLLGRFPE SSVLLSWGND SEHQVVMRIA
AAIGTGARVI DRYPLKGLTA LLKKVDLVIG GDTGPVHLAA AVGTATVSFY RASDGKRSGP
RGDNHVIIQS PMPCSRCFRT RCDQDEECRR SITVEVVMHG VEKLLV
//
