ID B9NXH9_9RHOB Unreviewed; 361 AA.
AC B9NXH9;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Hydroxymethylglutaryl-coenzyme A reductase {ECO:0000313|EMBL:EEE35255.1};
DE EC=1.1.1.34 {ECO:0000313|EMBL:EEE35255.1};
GN ORFNames=RKLH11_3931 {ECO:0000313|EMBL:EEE35255.1};
OS Rhodobacteraceae bacterium KLH11.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae.
OX NCBI_TaxID=467661 {ECO:0000313|EMBL:EEE35255.1, ECO:0000313|Proteomes:UP000005135};
RN [1] {ECO:0000313|Proteomes:UP000005135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KLH11 {ECO:0000313|Proteomes:UP000005135};
RX PubMed=21742885; DOI=10.1128/jb.05556-11;
RA Zan J., Fricke W.F., Fuqua C., Ravel J., Hill R.T.;
RT "Genome Sequence of Ruegeria sp. Strain KLH11, an N-Acylhomoserine Lactone-
RT Producing Bacterium Isolated from the Marine Sponge Mycale laxissima.";
RL J. Bacteriol. 193:5011-5012(2011).
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
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DR EMBL; DS999533; EEE35255.1; -; Genomic_DNA.
DR AlphaFoldDB; B9NXH9; -.
DR STRING; 467661.RKLH11_3931; -.
DR eggNOG; COG1257; Bacteria.
DR HOGENOM; CLU_001734_2_2_5; -.
DR OrthoDB; 9794902at2; -.
DR Proteomes; UP000005135; Unassembled WGS sequence.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EEE35255.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005135}.
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 39467 MW; B8F88922423807E5 CRC64;
MTSFETRDGD TTSVQSRKNN LDPFTPIPTQ WVGPIEINGE HVDEKISVPL ATFETPLWPS
TARGARVSQH SGGIRCTLVD ERMSRSIMLR AQNGTVARSA WKALAARKDE IAEVIATTGR
FVRLLSMNSQ IIGNLIYIRM ECSTGDASGH NMVTKSADTV IEWILRQHPE LDYASISGNY
CCDKKTSAVN GILGRGKYVI AEIEIPREVA TRMLRTTPER MAQLNLEKNL IGGTVAGSLR
SANAHFANML LAFYLATGQD AANIVEGSQG IVHCEARDEA LYFSCTLPNL IVGTVGNGKN
NPQVNAHLER LGCREERTHG ENARRLACIC AATVLCGELS LMAAQTNPGE LMRAHIKMER
A
//
