ID B9QB13_TOXGV Unreviewed; 936 AA.
AC B9QB13; A0A0F7UVT6;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=DNA mismatch repair protein, putative {ECO:0000313|EMBL:CEL74292.1};
DE SubName: Full=MutS domain V domain-containing protein {ECO:0000313|EMBL:ESS32093.1};
GN ORFNames=BN1205_073500 {ECO:0000313|EMBL:CEL74292.1}, TGVEG_261000
GN {ECO:0000313|EMBL:ESS32093.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS32093.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS32093.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS32093.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS32093.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS32093.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL74292.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL74292.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
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DR EMBL; LN714497; CEL74292.1; -; Genomic_DNA.
DR EMBL; AAYL02000145; ESS32093.1; -; Genomic_DNA.
DR AlphaFoldDB; B9QB13; -.
DR STRING; 432359.B9QB13; -.
DR PaxDb; 5811-TGME49_061000; -.
DR EnsemblProtists; ESS32093; ESS32093; TGVEG_261000.
DR VEuPathDB; ToxoDB:TGVEG_261000; -.
DR eggNOG; KOG0219; Eukaryota.
DR OMA; CKTKIGE; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226}.
FT DOMAIN 696..712
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 419..450
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 936 AA; 102216 MW; 6103B9B1469060D9 CRC64;
MFSSFSRGGA SASGDASDLS PDVNEVDLDE VLCAVEFGKP ESGRNVGAGV SVVGVCLFDR
RAFKIQFCEF STTNDLAVLE GLLLQVRPSC VVSTEAGGAG GTGEGWRKKL ADLAAACECE
FVPVKKNSAD TASLHQDLAT LLVAEDSIKN HISRELQLKT AAAACAALLS QARLLSDDMY
IRQCTLETYP LGNYLRIDNA AAAALYLFPS SLQQSQQQAL LPLSAKSSGA SRASSLACAL
SAGGGISSVY ALMSRWCSTQ LGARRLFTCM SQPLVDKKKI EERYDIVELF QTDEAFRRQV
FCSHFKHVFD LDRLAGRFHR LASAAKDLDA DAAPRGKKGG IFSRVKLTLE DLVKLYDCAV
ECTSLETTLR GYAGIHRESL EKAFTEPLSE AVKSFSTFIN LVEFTIDMEE AKHGSFVISR
RFDSELASLL DKKEELRSRM NRERQKAEDD IPFASRKRDA EIVKLIEDNT MGFVLRVTKK
DQSAVLSSRG RYHQVRLNKS ELIFTTSELR GLCREFKDVA EAYAAMQNSL VEKALLVAAS
YWPAVEKLAE LLGMLDVLGA FAAAANAAPV PYVRPQIVEG DAGGLVLKAS RHPLLEIQPG
TSSFIANDVH LDRERRLAII TGPNMGGKST YIRQVALTVL LAQIGSFVPC ASCQLPIFTQ
VICRVGASDI QLRGVSTFLA EMVEAAAILR NANKQSLVVI DELGRGTSTY EGFGLAWAIA
KHLAAEAKCL SLFATHFHEM GQLCEEVPGV SNLHVSAAVN RETQQLAFLY RLQSGCVDQS
FGVHVAGFAG LPATVVERAR QKSAELEAVE RGEQERRESG HRGGRKRSRS LERDGGGAAP
QREGEPREER AEERGEGEGG EREQAREEWR ERRRAFGKLT RCLKELFEEG EAGDFVRRVT
NAREKIRQLK DAAAPPTWKE VQDGGRGPGP SVPVAA
//
