ID   B9SYI6_RICCO            Unreviewed;       308 AA.
AC   B9SYI6;
DT   24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   24-MAR-2009, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   SubName: Full=Isoflavone reductase, putative {ECO:0000313|EMBL:EEF31316.1};
DE            EC=1.3.1.45 {ECO:0000313|EMBL:EEF31316.1};
GN   ORFNames=RCOM_1288520 {ECO:0000313|EMBL:EEF31316.1};
OS   Ricinus communis (Castor bean).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae;
OC   Ricinus.
OX   NCBI_TaxID=3988 {ECO:0000313|Proteomes:UP000008311};
RN   [1] {ECO:0000313|Proteomes:UP000008311}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Hale {ECO:0000313|Proteomes:UP000008311};
RX   PubMed=20729833; DOI=10.1038/nbt.1674;
RA   Chan A.P., Crabtree J., Zhao Q., Lorenzi H., Orvis J., Puiu D.,
RA   Melake-Berhan A., Jones K.M., Redman J., Chen G., Cahoon E.B., Gedil M.,
RA   Stanke M., Haas B.J., Wortman J.R., Fraser-Liggett C.M., Ravel J.,
RA   Rabinowicz P.D.;
RT   "Draft genome sequence of the oilseed species Ricinus communis.";
RL   Nat. Biotechnol. 28:951-956(2010).
CC   -!- SIMILARITY: Belongs to the NmrA-type oxidoreductase family. Isoflavone
CC       reductase subfamily. {ECO:0000256|ARBA:ARBA00005725}.
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DR   EMBL; EQ974252; EEF31316.1; -; Genomic_DNA.
DR   RefSeq; XP_002531055.1; XM_002531009.2.
DR   AlphaFoldDB; B9SYI6; -.
DR   STRING; 3988.B9SYI6; -.
DR   GeneID; 8260312; -.
DR   KEGG; rcu:8260312; -.
DR   eggNOG; ENOG502QPMY; Eukaryota.
DR   InParanoid; B9SYI6; -.
DR   OrthoDB; 1082618at2759; -.
DR   Proteomes; UP000008311; Unassembled WGS sequence.
DR   GO; GO:0047526; F:2'-hydroxyisoflavone reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009807; P:lignan biosynthetic process; IEA:UniProt.
DR   CDD; cd05259; PCBER_SDR_a; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR008030; NmrA-like.
DR   InterPro; IPR045312; PCBER-like.
DR   PANTHER; PTHR43349:SF40; PHENYLCOUMARAN BENZYLIC ETHER REDUCTASE-LIKE PROTEIN FI1; 1.
DR   PANTHER; PTHR43349; PINORESINOL REDUCTASE-RELATED; 1.
DR   Pfam; PF05368; NmrA; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000313|EMBL:EEF31316.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008311}.
FT   DOMAIN          7..297
FT                   /note="NmrA-like"
FT                   /evidence="ECO:0000259|Pfam:PF05368"
SQ   SEQUENCE   308 AA;  33806 MW;  614663529B5D786A CRC64;
     MAEKSKILVI GGTGHIGKFI VKTSAKLGHQ TFALVRETAV SNPERSEIIE SFKSYGVTLI
     YGDIHDHESL VKAIKQVEVV ISTVGGLHIA EQVKIIAAIK EAGNVKRFLP SEFGGDVDRS
     HAVEPAASFF GLKAKIRRAI EAERIPYTYT VSNGFAGYYL PSLGQPNAHV PPRDNVVIFG
     DGNPKTITVA EEDIAAFTIK AVDDPRTLNK ILYMRPPANV LSFNEIVAIW EKKIGNTLHK
     IYIPEEQTLQ KIQEAPSPLN LMLALIHSAM VKGDATNYEI EDSSGVEASE LYPEVKYTTV
     DEFLGKFV
//