ID B9UN12_ORENI Unreviewed; 374 AA.
AC B9UN12;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=3beta-hydroxysteroid dehydrogenase type I {ECO:0000313|EMBL:ACJ24593.1, ECO:0000313|EMBL:ACJ24594.1};
GN Name=LOC100534568 {ECO:0000313|Ensembl:ENSONIP00000019759.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|EMBL:ACJ24593.1};
RN [1] {ECO:0000313|EMBL:ACJ24593.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Ovary {ECO:0000313|EMBL:ACJ24593.1}, and Testis
RC {ECO:0000313|EMBL:ACJ24594.1};
RX PubMed=19084575; DOI=10.1016/j.mce.2008.11.008;
RA Senthilkumaran B., Sudhakumari C.C., Wang D.S., Sreenivasulu G.,
RA Kobayashi T., Kobayashi H.K., Yoshikuni M., Nagahama Y.;
RT "Novel 3beta-hydroxysteroid dehydrogenases from gonads of the Nile tilapia:
RT phylogenetic significance and expression during reproductive cycle.";
RL Mol. Cell. Endocrinol. 299:146-152(2009).
RN [2] {ECO:0000313|Ensembl:ENSONIP00000019759.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; EU827279; ACJ24593.1; -; mRNA.
DR EMBL; EU827280; ACJ24594.1; -; mRNA.
DR RefSeq; NP_001266438.1; NM_001279509.1.
DR STRING; 8128.ENSONIP00000019759; -.
DR Ensembl; ENSONIT00000019776.2; ENSONIP00000019759.1; ENSONIG00000015700.2.
DR GeneID; 100534568; -.
DR KEGG; onl:100534568; -.
DR CTD; 3283; -.
DR eggNOG; KOG1430; Eukaryota.
DR GeneTree; ENSGT00940000155444; -.
DR HOGENOM; CLU_007383_6_3_1; -.
DR OMA; PKYSWEE; -.
DR OrthoDB; 3675908at2759; -.
DR TreeFam; TF354279; -.
DR BRENDA; 1.1.1.51; 4429.
DR Proteomes; UP000005207; Unplaced.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 2: Evidence at transcript level;
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 9..286
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 374 AA; 42132 MW; 211F0073A0988113 CRC64;
MSLRGDVCVV TGACGFLGKR LVRLLLEEEK MAEIRLLDKQ IQLQFLQSLE DCKGETKLRA
FEGDMRDSDF LIKCCRGASI VFHIASIIDI KDSVEYSEIY GVNVKGTQLL LEACIQENVA
SFIYTSTIEV IGPNSKGEPI INGSEDTVYD ITLDINYRKT KSEAEEKTLK TDGEVLQNGG
QLATCALRPA YIYGEGCRFL LGHMADGIKN RNVLLRMSLP EALVKPVYVG NVAAAHLQAA
RSLKDPQKRN AVGGKFYFVS DDTPPVSYSD FNHAVMSPLG FSIQEKPMMP LTLFYLLTFL
METVAWILRP FIRIVPPLNR QLLTMLNTPF SFSYEKAKRD LGYVPKYSWE EARKRTTEWL
ASQLPAERER ILSK
//
