ID BLH3_ARATH Reviewed; 524 AA.
AC Q9FWS9; Q0WW07; Q8W4I2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 149.
DE RecName: Full=BEL1-like homeodomain protein 3;
DE Short=BEL1-like protein 3;
GN Name=BLH3; OrderedLocusNames=At1g75410; ORFNames=F1B16.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Pidkowich M.S., Samach A., Modrusan Z., Haughn G.W.;
RT "A family of BEL1-like homeodomain (BLH) proteins in Arabidopsis
RT thaliana.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Milich R.J., Putterill J.J.;
RT "The BELL family of homeodomain proteins in Arabidopsis.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-431.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP GENE FAMILY ORGANIZATION.
RX PubMed=15120075; DOI=10.1016/j.cub.2004.04.032;
RA Smith H.M.S., Campbell B.C.C., Hake S.;
RT "Competence to respond to floral inductive signals requires the homeobox
RT genes PENNYWISE and POUND-FOOLISH.";
RL Curr. Biol. 14:812-817(2004).
RN [9]
RP INTERACTION WITH OFP1; OFP2; OFP3; OFP4; OFP5 AND OFP15.
RX PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT "A central role of Arabidopsis thaliana ovate family proteins in networking
RT and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
RN [10]
RP FUNCTION, AND INTERACTION WITH STM.
RX PubMed=16513846; DOI=10.1093/nar/gkl016;
RA Cole M., Nolte C., Werr W.;
RT "Nuclear import of the transcription factor SHOOT MERISTEMLESS depends on
RT heterodimerization with BLH proteins expressed in discrete sub-domains of
RT the shoot apical meristem of Arabidopsis thaliana.";
RL Nucleic Acids Res. 34:1281-1292(2006).
CC -!- FUNCTION: Transcription factor that is responsive of the nuclear import
CC of SHOOT MERISTEMLESS (STM). {ECO:0000269|PubMed:16513846}.
CC -!- SUBUNIT: May form heterodimeric complex with the TALE/KNOX protein STM.
CC Interacts with OFP1, OFP2, OFP3, OFP4, OFP5 and OFP15.
CC {ECO:0000269|PubMed:15781858, ECO:0000269|PubMed:16513846}.
CC -!- INTERACTION:
CC Q9FWS9; P48000: KNAT3; NbExp=3; IntAct=EBI-912915, EBI-1153908;
CC Q9FWS9; Q38874: STM; NbExp=4; IntAct=EBI-912915, EBI-530523;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DOMAIN: The SR/KY and BELL domains are responsive for the interaction
CC between the TALE/BELL proteins and the TALE/KNOX proteins.
CC -!- SIMILARITY: Belongs to the TALE/BELL homeobox family. {ECO:0000305}.
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DR EMBL; AF353093; AAK43835.1; -; mRNA.
DR EMBL; AY598452; AAT09418.1; -; mRNA.
DR EMBL; AC023754; AAG13065.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35716.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35717.1; -; Genomic_DNA.
DR EMBL; AY062545; AAL32623.1; -; mRNA.
DR EMBL; BT000133; AAN15452.1; -; mRNA.
DR EMBL; AY085278; AAM62510.1; -; mRNA.
DR EMBL; AK226561; BAE98691.1; -; mRNA.
DR PIR; F96784; F96784.
DR RefSeq; NP_001077827.1; NM_001084358.2.
DR RefSeq; NP_177674.1; NM_106195.5.
DR AlphaFoldDB; Q9FWS9; -.
DR SMR; Q9FWS9; -.
DR BioGRID; 29096; 25.
DR IntAct; Q9FWS9; 22.
DR STRING; 3702.Q9FWS9; -.
DR iPTMnet; Q9FWS9; -.
DR PaxDb; 3702-AT1G75410-2; -.
DR ProteomicsDB; 222814; -.
DR EnsemblPlants; AT1G75410.1; AT1G75410.1; AT1G75410.
DR EnsemblPlants; AT1G75410.2; AT1G75410.2; AT1G75410.
DR GeneID; 843877; -.
DR Gramene; AT1G75410.1; AT1G75410.1; AT1G75410.
DR Gramene; AT1G75410.2; AT1G75410.2; AT1G75410.
DR KEGG; ath:AT1G75410; -.
DR Araport; AT1G75410; -.
DR TAIR; AT1G75410; BLH3.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_011058_6_1_1; -.
DR InParanoid; Q9FWS9; -.
DR OMA; NQQDGRY; -.
DR OrthoDB; 687102at2759; -.
DR PhylomeDB; Q9FWS9; -.
DR PRO; PR:Q9FWS9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FWS9; baseline and differential.
DR Genevisible; Q9FWS9; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0048510; P:regulation of timing of transition from vegetative to reproductive phase; IMP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR006563; POX_dom.
DR PANTHER; PTHR11850:SF286; BEL1-LIKE HOMEODOMAIN PROTEIN 3; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF07526; POX; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00574; POX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..524
FT /note="BEL1-like homeodomain protein 3"
FT /id="PRO_0000315459"
FT DNA_BIND 346..408
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 171..187
FT /note="SR/KY domain"
FT REGION 195..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..300
FT /note="BELL domain"
FT REGION 429..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 61
FT /note="V -> L (in Ref. 5; AAL32623/AAN15452)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 524 AA; 59679 MW; 94A2461E20FB3F39 CRC64;
MAVYYPNSVG MQSLYQESIY LNEQQQQQQQ ASSSSAASFS EIVSGDVRNN EMVFIPPTSD
VAVNGNVTVS SNDLSFHGGG LSLSLGNQIQ SAVSVSPFQY HYQNLSNQLS YNNLNPSTMS
DENGKSLSVH QHHSDQILPS SVYNNNGNNG VGFYNNYRYE TSGFVSSVLR SRYLKPTQQL
LDEVVSVRKD LKLGNKKMKN DKGQDFHNGS SDNITEDDKS QSQELSPSER QELQSKKSKL
LTMVDEVDKR YNQYHHQMEA LASSFEMVTG LGAAKPYTSV ALNRISRHFR CLRDAIKEQI
QVIRGKLGER ETSDEQGERI PRLRYLDQRL RQQRALHQQL GMVRPAWRPQ RGLPENSVSI
LRAWLFEHFL HPYPKESEKI MLSKQTGLSK NQVANWFINA RVRLWKPMIE EMYKEEFGES
AELLSNSNQD TKKMQETSQL KHEDSSSSQQ QNQGNNNNNI PYTSDAEQNL VFADPKPDRA
TTGDYDSLMN YHGFGIDDYN RYVGLGNQQD GRYSNPHQLH DFVV
//
