ID BOP1_DROPS Reviewed; 786 AA.
AC Q28XF0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 24-JAN-2024, entry version 92.
DE RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN ORFNames=GA18610;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CM000071; EAL26366.1; -; Genomic_DNA.
DR RefSeq; XP_001361787.1; XM_001361750.4.
DR AlphaFoldDB; Q28XF0; -.
DR SMR; Q28XF0; -.
DR STRING; 46245.Q28XF0; -.
DR EnsemblMetazoa; FBtr0280143; FBpp0278581; FBgn0078611.
DR GeneID; 4805377; -.
DR KEGG; dpo:4805377; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_2_0_1; -.
DR InParanoid; Q28XF0; -.
DR OMA; MRPAKGE; -.
DR PhylomeDB; Q28XF0; -.
DR Proteomes; UP000001819; Chromosome 3.
DR Bgee; FBgn0078611; Expressed in female reproductive system and 3 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17605:SF0; RIBOSOME BIOGENESIS PROTEIN BOP1; 1.
DR PANTHER; PTHR17605; RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..786
FT /note="Ribosome biogenesis protein BOP1 homolog"
FT /id="PRO_0000370400"
FT REPEAT 447..488
FT /note="WD 1"
FT REPEAT 490..528
FT /note="WD 2"
FT REPEAT 572..614
FT /note="WD 3"
FT REPEAT 617..655
FT /note="WD 4"
FT REPEAT 658..697
FT /note="WD 5"
FT REPEAT 701..740
FT /note="WD 6"
FT REPEAT 756..786
FT /note="WD 7"
FT REGION 1..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..40
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..71
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..102
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 90390 MW; 12618254F8A7972C CRC64;
MTKKLTIKRK VKEPEPQNEA PDSHESSDNE EEEEEDLLQA VKDPGEDSTD DEGIDQEYQT
DSSEDLEFES DEEGNYLGRK GAEGSSGDDD EESAEDEEEE DDADAKKSSK NNDEEAATTS
KSIKKSQEKP TSSNKVVPVV PARDPSKVEY ADSDTSDEED IRNTVGNIPM HWYDEYKHIG
YDWDAKKIVK PPKGDQIDDF LRKIEDPNFW RTVKDPLTGQ EVLLTDADIA LIKRINSGRI
PNEEHDEYAP WIEWFTSEVE KMPIKNVPDH KRSFLPSGSE KKTVSRMVHA LKMGWMKTTE
EVQREKQEKR GPKFYMLWET DTSREQMRRI HDPVSAPKRD LPGHAESYNP PPEYLFDEKE
AKEWHKLKDE PHRRKLHFMP QKFKSLREVP AYSRYLRERF LRCLDLYLCP RAKRVKLNID
AEYLIPKLPS PRDLQPFPTV ESLVYRGHTD LVRSVSVEPK GEYLVSGSDD KTVKIWEIAT
GRCIRTIETE DVVRCVAWCP NAKLSIIAVA TGSRLLLVNP KVGDKLLVKK TDDLLAEAPV
LDVIENERIK TAVQWANAEP ADQEKGVRVI ITHFKPIRQV TWHGRGDYLA TVMPEGANRS
ALIHQLSKRR SQIPFSKSKG LIQCVLFHPV KPCFFVATQH NIRIYDLVKQ ELIKKLLTNS
KWISGMSIHP KGDNLLVSTY DKKMLWFDLD LSTKPYQTMR LHRNAVRSVA FHLRYPLFAS
GSDDQAVIVS HGMVYNDLLQ NPLIVPLKKL QTHEKREEFG VLDVNWHPVQ PWVFSTGADC
TIRLFT
//
