ID BPIB3_HUMAN Reviewed; 472 AA.
AC P59826; Q5TDX7;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 24-JAN-2024, entry version 151.
DE RecName: Full=BPI fold-containing family B member 3 {ECO:0000305};
DE AltName: Full=Ligand-binding protein RYA3;
DE AltName: Full=Long palate, lung and nasal epithelium carcinoma-associated protein 3;
DE Flags: Precursor;
GN Name=BPIFB3 {ECO:0000312|HGNC:HGNC:16178}; Synonyms=C20orf185, LPLUNC3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC TISSUE=Fetal brain;
RX PubMed=12837268; DOI=10.1016/s0888-7543(03)00102-2;
RA Andrault J.-B., Gaillard I., Giorgi D., Rouquier S.;
RT "Expansion of the BPI family by duplication on human chromosome 20:
RT characterization of the RY gene cluster in 20q11.21 encoding olfactory
RT transporters/antimicrobial-like peptides.";
RL Genomics 82:172-184(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=11971875; DOI=10.1093/hmg/11.8.937;
RA Bingle C.D., Craven C.J.;
RT "PLUNC: a novel family of candidate host defence proteins expressed in the
RT upper airways and nasopharynx.";
RL Hum. Mol. Genet. 11:937-943(2002).
CC -!- FUNCTION: May have the capacity to recognize and bind specific classes
CC of odorants. May act as a carrier molecule, transporting odorants
CC across the mucus layer to access receptor sites. May serve as a primary
CC defense mechanism by recognizing and removing potentially harmful
CC odorants or pathogenic microorganisms from the mucosa or clearing
CC excess odorant from mucus to enable new odorant stimuli to be received
CC (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC P59826; Q03828: EVX2; NbExp=3; IntAct=EBI-1055244, EBI-17280301;
CC P59826; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-1055244, EBI-741158;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm
CC {ECO:0000269|PubMed:12837268}. Note=According to PubMed:12837268, it is
CC cytoplasmic.
CC -!- TISSUE SPECIFICITY: Detected in nasal septal epithelium.
CC {ECO:0000269|PubMed:11971875}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP84989.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF549189; AAP84989.1; ALT_INIT; mRNA.
DR EMBL; AL121756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS13212.2; -.
DR RefSeq; NP_872599.1; NM_182658.2.
DR AlphaFoldDB; P59826; -.
DR SMR; P59826; -.
DR BioGRID; 131704; 5.
DR IntAct; P59826; 3.
DR STRING; 9606.ENSP00000364643; -.
DR GlyCosmos; P59826; 3 sites, No reported glycans.
DR GlyGen; P59826; 3 sites.
DR iPTMnet; P59826; -.
DR PhosphoSitePlus; P59826; -.
DR BioMuta; BPIFB3; -.
DR DMDM; 73620973; -.
DR jPOST; P59826; -.
DR MassIVE; P59826; -.
DR PaxDb; 9606-ENSP00000364643; -.
DR PeptideAtlas; P59826; -.
DR TopDownProteomics; P59826; -.
DR Antibodypedia; 59271; 70 antibodies from 15 providers.
DR DNASU; 359710; -.
DR Ensembl; ENST00000375494.4; ENSP00000364643.4; ENSG00000186190.8.
DR GeneID; 359710; -.
DR KEGG; hsa:359710; -.
DR MANE-Select; ENST00000375494.4; ENSP00000364643.4; NM_001376932.3; NP_001363861.2.
DR UCSC; uc002wym.1; human.
DR AGR; HGNC:16178; -.
DR CTD; 359710; -.
DR GeneCards; BPIFB3; -.
DR HGNC; HGNC:16178; BPIFB3.
DR HPA; ENSG00000186190; Not detected.
DR MIM; 615717; gene.
DR neXtProt; NX_P59826; -.
DR PharmGKB; PA25727; -.
DR VEuPathDB; HostDB:ENSG00000186190; -.
DR eggNOG; KOG4160; Eukaryota.
DR GeneTree; ENSGT01100000263546; -.
DR HOGENOM; CLU_031635_1_0_1; -.
DR InParanoid; P59826; -.
DR OrthoDB; 5263773at2759; -.
DR PhylomeDB; P59826; -.
DR TreeFam; TF315617; -.
DR PathwayCommons; P59826; -.
DR SignaLink; P59826; -.
DR BioGRID-ORCS; 359710; 9 hits in 1142 CRISPR screens.
DR GenomeRNAi; 359710; -.
DR Pharos; P59826; Tbio.
DR PRO; PR:P59826; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; P59826; Protein.
DR Bgee; ENSG00000186190; Expressed in olfactory segment of nasal mucosa and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; NAS:UniProtKB.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR46019:SF5; BPI FOLD-CONTAINING FAMILY B MEMBER 3; 1.
DR PANTHER; PTHR46019; BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR SMART; SM00328; BPI1; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..472
FT /note="BPI fold-containing family B member 3"
FT /id="PRO_0000017170"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 284
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 160..195
FT /evidence="ECO:0000250"
FT VARIANT 224
FT /note="V -> M (in dbSNP:rs4911290)"
FT /id="VAR_049742"
FT VARIANT 286
FT /note="T -> M (in dbSNP:rs2093066)"
FT /id="VAR_049743"
FT VARIANT 330
FT /note="H -> Q (in dbSNP:rs6057717)"
FT /id="VAR_049744"
FT VARIANT 365
FT /note="Y -> C (in dbSNP:rs6059063)"
FT /id="VAR_049745"
FT VARIANT 445
FT /note="P -> S (in dbSNP:rs378098)"
FT /id="VAR_049746"
SQ SEQUENCE 472 AA; 49887 MW; 58541CB74C738E49 CRC64;
MLALWSLLLL WGLATPCQEL LETVGTLARI DKDELGKAIQ NSLVGEPILQ NVLGSVTAVN
RGLLGSGGLL GGGGLLGHGG VFGVVEELSG LKIEELTLPK VLLKLLPGFG VQLSLHTKVG
MHCSGPLGGL LQLAAEVNVT SRVALAVSSR GTPILILKRC STLLGHISLF SGLLPTPLFG
VVEQMLFKVL PGLLCPVVDS VLGVVNELLG AVLGLVSLGA LGSVEFSLAT LPLISNQYIE
LDINPIVKSV AGDIIDFPKS RAPAKVPPKK DHTSQVMVPL YLFNTTFGLL QTNGALDMDI
TPELVPSDVP LTTTDLAALL PEALGKLPLH QQLLLFLRVR EAPTVTLHNK KALVSLPANI
HVLFYVPKGT PESLFELNSV MTVRAQLAPS ATKLHISLSL ERLSVKVASS FTHAFDGSRL
EEWLSHVVGA VYAPKLNVAL DVGIPLPKVL NINFSNSVLE IVENAVVLTV AS
//
