ID BTBD9_MOUSE Reviewed; 612 AA.
AC Q8C726;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 146.
DE RecName: Full=BTB/POZ domain-containing protein 9;
GN Name=Btbd9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=22658601; DOI=10.1016/j.cub.2012.04.027;
RA Freeman A., Pranski E., Miller R.D., Radmard S., Bernhard D., Jinnah H.A.,
RA Betarbet R., Rye D.B., Sanyal S.;
RT "Sleep fragmentation and motor restlessness in a Drosophila model of
RT Restless Legs Syndrome.";
RL Curr. Biol. 22:1142-1148(2012).
CC -!- TISSUE SPECIFICITY: Expressed in the brain (at protein level).
CC {ECO:0000269|PubMed:22658601}.
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DR EMBL; AK052664; BAC35088.1; -; mRNA.
DR EMBL; BC057897; AAH57897.1; -; mRNA.
DR CCDS; CCDS28599.1; -.
DR RefSeq; NP_081336.1; NM_027060.1.
DR RefSeq; NP_766206.1; NM_172618.2.
DR AlphaFoldDB; Q8C726; -.
DR SMR; Q8C726; -.
DR BioGRID; 230301; 5.
DR IntAct; Q8C726; 1.
DR STRING; 10090.ENSMUSP00000127300; -.
DR iPTMnet; Q8C726; -.
DR PhosphoSitePlus; Q8C726; -.
DR MaxQB; Q8C726; -.
DR PaxDb; 10090-ENSMUSP00000127300; -.
DR ProteomicsDB; 265316; -.
DR Antibodypedia; 29854; 125 antibodies from 19 providers.
DR Ensembl; ENSMUST00000079924.8; ENSMUSP00000078845.6; ENSMUSG00000062202.15.
DR Ensembl; ENSMUST00000168787.8; ENSMUSP00000127300.2; ENSMUSG00000062202.15.
DR Ensembl; ENSMUST00000237048.2; ENSMUSP00000157449.2; ENSMUSG00000062202.15.
DR GeneID; 224671; -.
DR KEGG; mmu:224671; -.
DR UCSC; uc008btt.2; mouse.
DR AGR; MGI:1916625; -.
DR CTD; 114781; -.
DR MGI; MGI:1916625; Btbd9.
DR VEuPathDB; HostDB:ENSMUSG00000062202; -.
DR eggNOG; KOG4350; Eukaryota.
DR GeneTree; ENSGT00940000158298; -.
DR HOGENOM; CLU_004253_0_2_1; -.
DR InParanoid; Q8C726; -.
DR OMA; FHFAPRP; -.
DR OrthoDB; 9604at2759; -.
DR PhylomeDB; Q8C726; -.
DR TreeFam; TF318638; -.
DR BioGRID-ORCS; 224671; 3 hits in 77 CRISPR screens.
DR ChiTaRS; Btbd9; mouse.
DR PRO; PR:Q8C726; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8C726; Protein.
DR Bgee; ENSMUSG00000062202; Expressed in interventricular septum and 246 other cell types or tissues.
DR ExpressionAtlas; Q8C726; baseline and differential.
DR Genevisible; Q8C726; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0008344; P:adult locomotory behavior; IMP:MGI.
DR GO; GO:0048512; P:circadian behavior; IMP:MGI.
DR GO; GO:0042748; P:circadian sleep/wake cycle, non-REM sleep; IMP:MGI.
DR GO; GO:0007616; P:long-term memory; IMP:MGI.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IDA:SynGO.
DR GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IMP:MGI.
DR GO; GO:1900242; P:regulation of synaptic vesicle endocytosis; IMP:MGI.
DR GO; GO:0050951; P:sensory perception of temperature stimulus; IMP:MGI.
DR GO; GO:0042428; P:serotonin metabolic process; IMP:MGI.
DR CDD; cd14822; BACK_BTBD9; 1.
DR CDD; cd18287; BTB_POZ_BTBD9; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR034091; BTBD9_BACK-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR46306; BTB/POZ DOMAIN-CONTAINING PROTEIN 9; 1.
DR PANTHER; PTHR46306:SF1; BTB_POZ DOMAIN-CONTAINING PROTEIN 9; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00754; F5_F8_type_C; 2.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..612
FT /note="BTB/POZ domain-containing protein 9"
FT /id="PRO_0000186218"
FT DOMAIN 36..104
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 142..240
FT /note="BACK"
FT REGION 559..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 69148 MW; D564B2DB24F0D9FF CRC64;
MSNSHPLRPF TAVGEIDHVH ILSEHIGALL IGEEYGDVTF VVEKKHFPAH RVILAARCQY
FRALLYGGMR ESQPEAEIPL QDTTAEAFTM LLRYIYTGRA TLTDEKEEVL LDFLSLAHKY
GFPELEDSTS EYLCTILNIQ NVCMTFDVAS LYSLPKLTCM CCMFMDRNAQ EVLASDGFLS
LSKTALLNIV LRDSFAAPEK DIFLALLNWC KHNAKENHAE IMQAVRLPLM SLTELLNVVR
PSGLLSPDAI LDAIKVRSES RDMDLNYRGM LIPEENIATM KYGAQVVKGE LKSALLDGDT
QNYDLDHGFS RHPIDDDCRS GIEIKLGQPS IINHIRLLLW DRDSRSYSYF IEVSMDELDW
IRVIDHSHYL CRSWQKLYFP ARVCRYIRIV GTHNTVNKIF HIVAFECMFT NKAFTLEKGL
IVPLENVATI ADCASVIEGV SRSRNALLNG DTKNYDWDSG YTCHQLGSGA IVVQLAQPYI
IGSIRLLLWD CDDRSYSYYV EVSTNQQQWT MVADRTKVSC KSWQSVTFER QPASFIRIVG
THNTANEVFH CVHFECPEQQ SNQKEDSSEE PGTGDPSTPN QQLDPHAPRA PSASSLPPSP
GPNSRSPNQQ NQ
//
