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Database: UniProt
Entry: C0AV77_9GAMM
LinkDB: C0AV77_9GAMM
Original site: C0AV77_9GAMM 
ID   C0AV77_9GAMM            Unreviewed;       245 AA.
AC   C0AV77;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   03-JUL-2019, entry version 56.
DE   RecName: Full=Ubiquinone biosynthesis O-methyltransferase {ECO:0000256|HAMAP-Rule:MF_00472};
DE   AltName: Full=2-polyprenyl-6-hydroxyphenol methylase {ECO:0000256|HAMAP-Rule:MF_00472};
DE            EC=2.1.1.222 {ECO:0000256|HAMAP-Rule:MF_00472};
DE   AltName: Full=3-demethylubiquinone 3-O-methyltransferase {ECO:0000256|HAMAP-Rule:MF_00472};
DE            EC=2.1.1.64 {ECO:0000256|HAMAP-Rule:MF_00472};
GN   Name=ubiG {ECO:0000256|HAMAP-Rule:MF_00472,
GN   ECO:0000313|EMBL:EEG85906.1};
GN   ORFNames=PROPEN_01729 {ECO:0000313|EMBL:EEG85906.1};
OS   Proteus penneri ATCC 35198.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=471881 {ECO:0000313|EMBL:EEG85906.1, ECO:0000313|Proteomes:UP000006464};
RN   [1] {ECO:0000313|EMBL:EEG85906.1, ECO:0000313|Proteomes:UP000006464}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35198 {ECO:0000313|EMBL:EEG85906.1,
RC   ECO:0000313|Proteomes:UP000006464};
RA   Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H.,
RA   Johnson M., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEG85906.1, ECO:0000313|Proteomes:UP000006464}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35198 {ECO:0000313|EMBL:EEG85906.1,
RC   ECO:0000313|Proteomes:UP000006464};
RA   Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M.,
RA   Liep D., Gordon J.;
RT   "Draft genome sequence of Proteus penneri (ATCC 35198).";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: O-methyltransferase that catalyzes the 2 O-methylation
CC       steps in the ubiquinone biosynthetic pathway. {ECO:0000256|HAMAP-
CC       Rule:MF_00472, ECO:0000256|SAAS:SAAS00561163}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-
CC         L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+)
CC         + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:31411, Rhea:RHEA-
CC         COMP:9550, Rhea:RHEA-COMP:9551, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:62729,
CC         ChEBI:CHEBI:62731; EC=2.1.1.222; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00472, ECO:0000256|SAAS:SAAS01122591};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-demethylubiquinol + S-adenosyl-L-methionine = a
CC         ubiquinol + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:44380, Rhea:RHEA-COMP:9566, Rhea:RHEA-COMP:10914,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17976, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:84422; EC=2.1.1.64;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00472,
CC         ECO:0000256|SAAS:SAAS01122587};
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00472, ECO:0000256|SAAS:SAAS00063519}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       UbiG/COQ3 family. {ECO:0000256|HAMAP-Rule:MF_00472,
CC       ECO:0000256|SAAS:SAAS01087951}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EEG85906.1}.
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DR   EMBL; ABVP01000023; EEG85906.1; -; Genomic_DNA.
DR   STRING; 471881.PROPEN_01729; -.
DR   EnsemblBacteria; EEG85906; EEG85906; PROPEN_01729.
DR   eggNOG; ENOG4108HWB; Bacteria.
DR   eggNOG; COG2227; LUCA.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000006464; Unassembled WGS sequence.
DR   GO; GO:0008425; F:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008689; F:3-demethylubiquinone-9 3-O-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00472; UbiG; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   InterPro; IPR010233; UbiG_MeTrfase.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR01983; UbiG; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006464};
KW   Methyltransferase {ECO:0000256|HAMAP-Rule:MF_00472,
KW   ECO:0000256|SAAS:SAAS00448101, ECO:0000313|EMBL:EEG85906.1};
KW   S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_00472,
KW   ECO:0000256|SAAS:SAAS00448117};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00472,
KW   ECO:0000256|SAAS:SAAS00448111, ECO:0000313|EMBL:EEG85906.1};
KW   Ubiquinone {ECO:0000313|EMBL:EEG85906.1};
KW   Ubiquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_00472,
KW   ECO:0000256|SAAS:SAAS00063552}.
FT   BINDING      44     44       S-adenosyl-L-methionine.
FT                                {ECO:0000256|HAMAP-Rule:MF_00472}.
FT   BINDING      64     64       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen. {ECO:0000256|HAMAP-Rule:
FT                                MF_00472}.
FT   BINDING      85     85       S-adenosyl-L-methionine.
FT                                {ECO:0000256|HAMAP-Rule:MF_00472}.
FT   BINDING     129    129       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen. {ECO:0000256|HAMAP-Rule:
FT                                MF_00472}.
SQ   SEQUENCE   245 AA;  27469 MW;  FE03C9C849B609B5 CRC64;
     MNDKTISLHA NVDQHEIDKF ESVASRWWDL EGEFKPLHRI NPLRLNYIQE RADGLFGKKV
     LDVGCGGGIL SESMACVGAE VTGLDMGTEP LQVARLHSLE SGIPVTYIQD TVENHANENP
     QNYDVVTCME MLEHVPDPSS VVRACAKLVK PGGHVFFSTI NRNKKAWLML VVGAEYILNM
     VPKGTHDANK FIRPSELLSW VDETDLRCKN MIGLHYNPIT DKFRLAPNVD VNYMVHTQST
     HNSNS
//
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