ID C0C4R1_9FIRM Unreviewed; 586 AA.
AC C0C4R1;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Na+/H+ antiporter family protein {ECO:0000313|EMBL:EEG73054.1};
GN ORFNames=CLOHYLEM_07077 {ECO:0000313|EMBL:EEG73054.1};
OS [Clostridium] hylemonae DSM 15053.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=553973 {ECO:0000313|EMBL:EEG73054.1, ECO:0000313|Proteomes:UP000004893};
RN [1] {ECO:0000313|EMBL:EEG73054.1, ECO:0000313|Proteomes:UP000004893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15053 {ECO:0000313|EMBL:EEG73054.1,
RC ECO:0000313|Proteomes:UP000004893};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Clostridium hylemonae (DSM 15053).";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEG73054.1, ECO:0000313|Proteomes:UP000004893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15053 {ECO:0000313|EMBL:EEG73054.1,
RC ECO:0000313|Proteomes:UP000004893};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEG73054.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABYI02000034; EEG73054.1; -; Genomic_DNA.
DR AlphaFoldDB; C0C4R1; -.
DR STRING; 553973.CLOHYLEM_07077; -.
DR eggNOG; COG1757; Bacteria.
DR HOGENOM; CLU_018751_1_0_9; -.
DR Proteomes; UP000004893; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR43478; NA+/H+ ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR43478:SF1; NA_H_ANTIPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 537..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 242..556
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 586 AA; 63065 MW; 22E27F608874CDF8 CRC64;
MYRDIYYAVN APPESVVHGV FVMWGVCGLA HTYHRNSGKT REERGSKMNK RSKKIVWGTL
VLLLMLACSS LTVFAAEDAA EYVPDMYASF WALIPPVVAI VLALITKEVY SSLFIGILMG
GIFYSNFTFE KTITHVFQDG IIGVLSDSYN VGILVFLVIL GVMVCLMNKA GGSAAFGRWA
AEHIKSRVGA QLATIVLGVL IFIDDYFNCL TVGSVMRPVT DKHNISRAKL SYLIDATAAP
VCIIAPISSW AAAVTGFVEG EDGLSIFIRA IPYNFYALLT IVMMLGLVFM KVDYGPMRLH
EINAAKGDLY TTPDRPYANA EPESGEESRG KVIDLVFPII LLIICCVIGM IYTGGFFTGA
DFVTAFSQSD ASVGLVLGSF FAFALTIIFY VVRRVMKFGE CMSCIPDGFK AMVPAILILT
LAWSLKAMTD SLGAAAYVEA IMKSSAKGFV TLLPAIIFLV GCFLAFATGT SWGTFGILIP
IVVAVFAGSN ENMMIISISA CMAGAVCGDH CSPISDTTIM ASAGAQCNHV NHVTTQLPYA
VTVAAVSFVT YIVAGFVQSA WIALPVGVVL MLLVLFVIRV GNVDKV
//
