ID C0C5U9_9FIRM Unreviewed; 976 AA.
AC C0C5U9;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=Stage 0 sporulation protein A homolog {ECO:0000256|ARBA:ARBA00018672};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=CLOHYLEM_07486 {ECO:0000313|EMBL:EEG72483.1};
OS [Clostridium] hylemonae DSM 15053.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=553973 {ECO:0000313|EMBL:EEG72483.1, ECO:0000313|Proteomes:UP000004893};
RN [1] {ECO:0000313|EMBL:EEG72483.1, ECO:0000313|Proteomes:UP000004893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15053 {ECO:0000313|EMBL:EEG72483.1,
RC ECO:0000313|Proteomes:UP000004893};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Clostridium hylemonae (DSM 15053).";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEG72483.1, ECO:0000313|Proteomes:UP000004893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15053 {ECO:0000313|EMBL:EEG72483.1,
RC ECO:0000313|Proteomes:UP000004893};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play the central regulatory role in sporulation. It may
CC be an element of the effector pathway responsible for the activation of
CC sporulation genes in response to nutritional stress. Spo0A may act in
CC concert with spo0H (a sigma factor) to control the expression of some
CC genes that are critical to the sporulation process.
CC {ECO:0000256|ARBA:ARBA00024867}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEG72483.1}.
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DR EMBL; ABYI02000041; EEG72483.1; -; Genomic_DNA.
DR AlphaFoldDB; C0C5U9; -.
DR STRING; 553973.CLOHYLEM_07486; -.
DR eggNOG; COG0642; Bacteria.
DR eggNOG; COG0834; Bacteria.
DR HOGENOM; CLU_000445_114_9_9; -.
DR Proteomes; UP000004893; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 4.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00497; SBP_bac_3; 2.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00062; PBPb; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 2.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EEG72483.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EEG72483.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 43..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 599..820
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 844..965
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 896
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 976 AA; 109121 MW; CD0C782711331124 CRC64;
MCEAAETGQF MWQNSPRHGK IVTGDFKKEF CMKNRSRLEI KKCGVVLLLL AAALTAVLVP
CAGARAKEPQ SGKVLKVAFA QVPGFTETDK NGNRRGIVVD YLNEIAKYTG WEYEYIDTDG
ETMVDEFLEG RYDLMGGTYY QEGLEEYFAY PDYNTGYSKS VLLASREDDS IKAYDWKSLS
GKTIGVYERA VENIRRLKVF LDSNGIDCTL KTYSAEQLTD GNMYSYLENG EVDMILGNLG
SDADVFRVVA EFDSQPHYIV TKPEDKEILD GLNMALGKIV DSNPHFAQER YDANIQDSST
ANITLNDEEK KYVEEKKTVS VAVLKEWHPL YCRELKKDLH DGIIPDILEE IKEFSGLTFS
YKYVDSYAEG LQMVENGEAD LFGAFLGTDE EAAQKEMALT KPYVVLNDII ERNKSVSYPS
EGLTGAVLEG RELPAEIEAS EVKYYSNTAE ALRAVDQGEA DFYYGVSAIM EQEIQNHHFT
NVVPNTLIND RNDISFAMKR PAPGQLLTIM NKAINSLSST QKDTIANQNM ISSGTGEMTI
IEMIYANPLM FVVICGVVFL LIVILILVMA RYRIHAVRMQ NSLAKAEKEN RAKGEFLSRM
SHEIRTPMNA IVGLSDLTCM MDDVPETVRV NLSKIRSSSR YLLGLISDIL DMSRIEQDMM
TIVREPFSIG QVMNELESMM TAEAGRRELE FKLDLRIKSD RLIGDAVRLK QVLMNLISNA
FKFTSAGGRI RVDVTETEAS AEEAVFCFRV ADNGIGISEK DQERIFESFE QVGTNYSKSQ
GTGLGLAISK NIVELMGGKL ELKSEIGKGS EFYFTAAFPT AASEEVHDES PAVDMPKRYL
RDMCILLAED NDLNAEIAEE LLEMQGAAVR RARNGRDAVK MFEDSAPGEF HAILMDIQMP
VMDGLEACRV IRGMKREDAA VIPVIAMTAN TFKEDVDMAA EAGMDGFVTK PVDVEYLYQV
LCKAVRRDRP AQPDVL
//