ID   C0EF25_9FIRM            Unreviewed;       482 AA.
AC   C0EF25;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=MutS domain I protein {ECO:0000313|EMBL:EEG29927.1};
GN   ORFNames=CLOSTMETH_02464 {ECO:0000313|EMBL:EEG29927.1};
OS   [Clostridium] methylpentosum DSM 5476.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Oscillospiraceae incertae sedis.
OX   NCBI_TaxID=537013 {ECO:0000313|EMBL:EEG29927.1, ECO:0000313|Proteomes:UP000003340};
RN   [1] {ECO:0000313|EMBL:EEG29927.1, ECO:0000313|Proteomes:UP000003340}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 5476 {ECO:0000313|EMBL:EEG29927.1,
RC   ECO:0000313|Proteomes:UP000003340};
RA   Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA   Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEG29927.1, ECO:0000313|Proteomes:UP000003340}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 5476 {ECO:0000313|EMBL:EEG29927.1,
RC   ECO:0000313|Proteomes:UP000003340};
RA   Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA   Gordon J.;
RT   "Draft genome sequence of Clostridium methylpentosum (DSM 5476).";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEG29927.1}.
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DR   EMBL; ACEC01000082; EEG29927.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0EF25; -.
DR   STRING; 537013.CLOSTMETH_02464; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_9_2_9; -.
DR   Proteomes; UP000003340; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 1.10.1420.10; -; 1.
DR   Gene3D; 6.10.140.80; -; 1.
DR   Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR   Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR   SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003340}.
FT   DOMAIN          283..482
FT                   /note="DNA mismatch repair protein MutS core"
FT                   /evidence="ECO:0000259|SMART:SM00533"
SQ   SEQUENCE   482 AA;  54543 MW;  00B5E12B5CBCADD7 CRC64;
     MMQQYKQIKE RHKDHLLFFR LGDFYELFFD DAILASKELE LTLTGRDCGL EERAPMCGVP
     FHSVDTYIKR LVTKGYKVAI CEQTENPAFA KGIVSREVIR VITPGTIAEG NMLEEGKNNY
     ICSVYVEKKS FGISFADVST GIAYTSEFRS SNLTADIINE LQRFSPSEIL FNEAFVDLKE
     VAHYLKTKMQ CTGELLMEEE YSASQARELV QKQFGKTPQQ AGLENSPLAL RSLGALLGYI
     VETQKDGAKR IVNLTVYNDE QYLSIDLTAR RNLELTETMR SGEKKGSLLW VLDRTKTSMG
     KRLMRKTIEQ PLIGPAKILK RQAAVGELIS QPVVRGEIIS LLSNVYDLER LMTKVIYGSV
     SPRELKALSF TAQHLPQLKE QLALLGAPLL AELNGKMADM TELHNLIENA VIDEPPINLK
     EGGVIKPGFN EELDELRGIR DNGKDYILKL EEREKERTGI KKLKISYNRV FGYYIEVTKS
     FL
//