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Database: UniProt
Entry: C0EHU6_9FIRM
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ID   C0EHU6_9FIRM            Unreviewed;       393 AA.
AC   C0EHU6;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 45.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=CLOSTMETH_03441 {ECO:0000313|EMBL:EEG28918.1};
OS   [Clostridium] methylpentosum DSM 5476.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   unclassified Ruminococcaceae.
OX   NCBI_TaxID=537013 {ECO:0000313|EMBL:EEG28918.1, ECO:0000313|Proteomes:UP000003340};
RN   [1] {ECO:0000313|EMBL:EEG28918.1, ECO:0000313|Proteomes:UP000003340}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 5476 {ECO:0000313|EMBL:EEG28918.1,
RC   ECO:0000313|Proteomes:UP000003340};
RA   Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H.,
RA   Johnson M., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEG28918.1, ECO:0000313|Proteomes:UP000003340}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 5476 {ECO:0000313|EMBL:EEG28918.1,
RC   ECO:0000313|Proteomes:UP000003340};
RA   Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M.,
RA   Liep D., Gordon J.;
RT   "Draft genome sequence of Clostridium methylpentosum (DSM 5476).";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EEG28918.1}.
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DR   EMBL; ACEC01000122; EEG28918.1; -; Genomic_DNA.
DR   STRING; 537013.CLOSTMETH_03441; -.
DR   EnsemblBacteria; EEG28918; EEG28918; CLOSTMETH_03441.
DR   eggNOG; ENOG4105E99; Bacteria.
DR   eggNOG; COG0722; LUCA.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000003340; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003340};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003340};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:EEG28918.1}.
FT   DOMAIN       82    384       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   393 AA;  44581 MW;  EDF447D67081642A CRC64;
     MAAKAEGVQL GDRLLPLVRM RIVRYNKTCN WVYQHHFHKS KTQSGLEEFY MSMKCNKELP
     LPTDLKAEFP LSQKVMDIKE KRDREIRDIF TGKSDRFIVL VGPCSADNED AVCDYVNRLA
     RVNEQVSDKL MIIPRIYTNK PRTTGEGYKG MLHQPEPDKA PDLLAGIIAI RKMHIRAIEE
     TGLTAADEML YPENRSYLDD LLSYEAIGAR SVENQQHRLT ASGMDIPVGM KNPTSGDFSV
     MLNSVIAAQH PHTFIYRGCD VTTSGNDLAH VILRGGVDKY GTCVPNYHYE DLVRLLDQYS
     KLDLRNPAAI VDVNHSNSNK KFKEQIRIVS EVLHSRNYNP DLKKLIKGVM IESYLEEGNQ
     SIGAERVYGK SITDPCLGWP DTEKLIYRIA QSC
//
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